ArticleACS applied materials & interfaces2019
Two-Dimensional Black Phosphorus and Graphene Oxide Nanosheets Synergistically Enhance Cell Proliferation and Osteogenesis on 3D Printed Scaffolds.
Article in ACS applied materials & interfaces, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 127 citations in OpenAlex.
- Controlled drug release and electroconductive performance of 3D printed scaffolds for neural tissue regeneration.Journal of materials science. Materials in medicine · 2026Article
- Black phosphorus in theragenerative medicine: a multi-organ perspective on disease modulation and tissue repair.Bioactive materials · 2026Review
- 3D-Printed Sodium Alginate/Gelatin/Black Phosphorus Nanosheet Hydrogel Patches for Urethral Stricture Repair.International journal of biomaterials · 2026Article
- Novel Nanomaterials for Developing Bone Scaffolds and Tissue Regeneration.Nanomaterials (Basel, Switzerland) · 2025Review
- Graphene Oxide/Black Phosphorus Functionalized Collagen Scaffolds with Enhanced Near-Infrared Controlled In Situ Biomineralization for Promoting Infectious Bone Defect Repair through PI3K/Akt Pathway.ACS applied materials & interfaces · 2024Article
- Black phosphorus quantum dot-modified ADSCs as a novel therapeutic for periodontitis bone loss coupling of osteogenesis and osteoimmunomodulation.Materials today. Bio · 2024Article
- Review
- Surface Deformation of Biocompatible Materials: Recent Advances in Biological Applications.Biomimetics (Basel, Switzerland) · 2024Review
- A theragenerative bio-nanocomposite consisting of black phosphorus quantum dots for bone cancer therapy and regeneration.Bioactive materials · 2024Article
- Advances in the Application of Black Phosphorus-Based Composite Biomedical Materials in the Field of Tissue Engineering.Pharmaceuticals (Basel, Switzerland) · 2024Review
- 3D-printed scaffolds with 2D hetero-nanostructures and immunomodulatory cytokines provide pro-healing microenvironment for enhanced bone regeneration.Bioactive materials · 2023Article
- Research on the Antibacterial Properties of MXene-Based 2D-2D Composite Materials Membrane.Nanomaterials (Basel, Switzerland) · 2023Article
- Advances of Mussel-Inspired Nanocomposite Hydrogels in Biomedical Applications.Biomimetics (Basel, Switzerland) · 2023Review
- Research progress on black phosphorus hybrids hydrogel platforms for biomedical applications.Journal of biological engineering · 2023Review
- Advances in Conductive Hydrogel for Spinal Cord Injury Repair and Regeneration.International journal of nanomedicine · 2023Review
- Implications of graphene-based materials in dentistry: present and future.Frontiers in chemistry · 2023Review
- State-of-the-art techniques for promoting tissue regeneration: Combination of three-dimensional bioprinting and carbon nanomaterials.International journal of bioprinting · 2023Article
- Bioactive elements manipulate bone regeneration.Biomaterials translational · 2023Review
- The Application of Black Phosphorus Nanomaterials in Bone Tissue Engineering.Pharmaceutics · 2022Review
- An Insight of Nanomaterials in Tissue Engineering from Fabrication to Applications.Tissue engineering and regenerative medicine · 2022Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Two-dimensional (2D) materials have emerged as a new promising research topic for tissue engineering because of their ability to alter the surface properties of tissue scaffolds and thus improve their biocompatibility and cell affinity. Multiple 2D materials, such as graphene and graphene oxide (GO), have been widely reported to enhance cell adhesion and proliferation. Recently, a newly emerged black phosphorus (BP) 2D material has attracted attention in biomedical applications because of its unique mechanical and electrochemical characteristics. In this study, we investigated the synergistic effect of these two types of 2D materials on cell osteogenesis for bone tissue engineering. BP was first wrapped in negatively charged GO nanosheets, which were then adsorbed together onto positively charged poly(propylene fumarate) three-dimensional (3D) scaffolds. The increased surface area provided by GO nanosheets would enhance cell attachment at the initial stage. In addition, slow oxidation of BP nanosheets wrapped within GO layers would generate a continuous release of phosphate, an important osteoblast differentiation facilitator designed to stimulate cell osteogenesis toward the new bone formation. Through the use of 3D confocal imaging, unique interactions between cells and BP nanosheets were observed, including a stretched cell shape and the development of filaments around the BP nanosheets, along with increased cell proliferation when compared with scaffolds incorporating only one of the 2D materials. Furthermore, the biomineralization of 3D scaffolds, as well as cellular osteogenic markers, was all measured and improved on scaffolds with both BP and GO nanosheets. All these results indicate that the incorporation of 2D BP and GO materials could effectively and synergistically stimulate cell proliferation and osteogenesis on 3D tissue scaffolds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.