ArticleObesity (Silver Spring, Md.)2019
Neonatal Adipocytokines and Longitudinal Patterns of Childhood Growth.
Article in Obesity (Silver Spring, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Metabolic health conditions in pregnancy, human milk hormone concentrations, and infant adiposity.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Review
- Alterations in infant adipokine concentrations in the first postnatal week with exposure to diabetes in pregnancy.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Evaluating causal influence of maternal educational attainment on offspring birthweight via observational study and Mendelian randomization analyses.SSM - population health · 2024Article
- Infant factors that impact the ecology of human milk secretion and composition-a report from "Breastmilk Ecology: Genesis of Infant Nutrition (BEGIN)" Working Group 3.The American journal of clinical nutrition · 2023Review
- Serum Adipocytokines Profile in Children Born Small and Appropriate for Gestational Age-A Comparative Study.Nutrients · 2023Article
- Cord Blood Levels of Spexin, Leptin, and Visfatin in Term Infants Born Small, Appropriate, and Large for Gestational Age and Their Association with Newborn Anthropometric MeasurementsJournal of clinical research in pediatric endocrinology · 2022Article
- Neonatal and Adolescent Adipocytokines as Predictors of Adiposity and Cardiometabolic Risk in Adolescence.Obesity (Silver Spring, Md.) · 2021Article
- Mediation Analysis Supports a Causal Relationship between Maternal Hyperglycemia and Placental DNA Methylation Variations at the Leptin Gene Locus and Cord Blood Leptin Levels.International journal of molecular sciences · 2020Article
- Fetal Growth Trajectories and Their Association with Maternal, Cord Blood, and 5-year Child Adipokines.Journal of nutrition and metabolism · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveAdipocytokines are markers of fetal metabolism, but their association with childhood growth is unclear. This study examined associations of neonatal adipocytokines with longitudinal childhood adiposity measures in a prospective cohort of pregnant women and their children.
methodsLeptin and adiponectin concentrations at delivery and children's BMI z scores between age 4 weeks and 8 years were measured. Differences in BMI z scores and rates of BMI z score change by leptin (n = 257) and adiponectin (n = 271) terciles were estimated.
resultsChildren in the middle (mean difference: 0.2; 95% CI: -0.1 to 0.4) and highest (0.4; 95% CI: 0.1 to 0.6) leptin terciles had greater BMI z scores than children in the lowest tercile. Associations were null after adjustment for birth weight z score. Children in the lowest adiponectin tercile had greater gains in BMI z score (change per year: 0.10; 95% CI: 0.08 to 0.13) than children in the middle (0.07; 95% CI: 0.04 to 0.09) and highest terciles (0.04; 95% CI: -0.01 to 0.05) (adiponectin × age interaction P < 0.001).
conclusionsLower adiponectin levels were associated with increased rates of BMI gains in the first 8 years of life. Though leptin was positively associated with BMI, this association may be confounded by birth weight.
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