Evidence map›Paper›PMID 31198735›Full record

ArticleJournal of family medicine and primary care2019

Association of serum magnesium with type 2 diabetes mellitus and diabetic retinopathy.

Pratyush Kumar, Seema Bhargava, Pankaj Kumar Agarwal, Ambuj Garg, Amit Khosla

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Article in Journal of family medicine and primary care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
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  5. Assessment of trace element imbalances in diabetes mellitus patients with and without diabetic retinopathy: a case-control study in Iraq.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025
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  14. 'Magnesium'-the master cation-as a drug-possibilities and evidences.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2021
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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Pratyush KumarDepartment of Family Medicine, Sir Gangaram Hospital, New Delhi, India.
Seema BhargavaDepartment of Biochemistry, Sir Gangaram Hospital, New Delhi, India.
Pankaj Kumar AgarwalDepartment of Medicine, Sir Gangaram Hospital, New Delhi, India.
Ambuj GargDepartment of Medicine, Sir Gangaram Hospital, New Delhi, India.
Amit KhoslaDepartment of Ophthalmology, Sir Gangaram Hospital, New Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

INTRODUCTION AND

objectiveThe rising burden of type 2 diabetes mellitus (T2DM) globally has led to huge morbidity and socioeconomic impact in developing countries. In India, too, it has become a silent epidemic and it is estimated that there are over 60 million diabetics. Although in recent years, a lot of research papers have come up on the management of diabetes, latest treatment modalities may not be affordable to all. So, it becomes imperative to prioritize research on prevention and primary care. Magnesium is an intracellular cation and coenzyme for various reactions of the glycolytic pathway. Hypomagnesemia has been shown to precipitate hyperglycemia and has, therefore, been implicated in insulin resistance and its microvascular complications. Poor glycemic control has been associated with retinopathy. Hence, we evaluated association of serum magnesium with T2DM and diabetic retinopathy. MATERIALS AND

methodsIn a cross-sectional study in North India, 250 consenting adult patients from outpatient department of family medicine of our hospital were recruited. Critically ill patients and those on magnesium supplements were excluded. Clinicolaboratory profile was evaluated. Patients were divided based on serum magnesium level ≤ 1.7 mg/dL (group 1) and > 1.7 mg/dL (group 2). Glycemic control and proportion of diabetic retinopathy were compared between these two groups by using univariate regression analysis.

resultsOut of 250 patients, 110 patients (44%) were found to have hypomagnesemia. Glycemia by fasting blood sugar (

conclusionsMagnesium deficiency is associated with increased risk of diabetic retinopathy and poor glycemic control. Dietary supplementation may be advised to prevent such complications and improve glycemic control.

Indexed as

DiabetesmagnesiumretinopathyT2dm

Identifiers

PMID31198735
PMCPMC6559114

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