Evidence map›Paper›PMID 31198678›Full record

ArticleRespiratory medicine case reports2019

Pembrolizumab-associated bronchiolitis in an elderly lung cancer patient required the treatment with an inhaled corticosteroid, erythromycin and bronchodilators.

Takafumi Yamaya, Hwang Moon Hee, Takayuki Aoyagi, Tatsuya Ogimoto, Naoki Yamada, Ryoichi Ishikawa, Erika Nakai, Kenta Nishi, Chie Yoshimura, Yasuo Nishizaka

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory medicine case reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Takafumi YamayaDepartment of Respiratory Medicine, Japanese Red Cross Osaka Hospital, Osaka City, Japan.
Hwang Moon HeeDepartment of Respiratory Medicine, Japanese Red Cross Osaka Hospital, Osaka City, Japan.
Takayuki AoyagiDepartment of Respiratory Medicine, Japanese Red Cross Osaka Hospital, Osaka City, Japan.
Tatsuya OgimotoDepartment of Respiratory Medicine, Japanese Red Cross Osaka Hospital, Osaka City, Japan.
Naoki YamadaDepartment of Respiratory Medicine, Japanese Red Cross Osaka Hospital, Osaka City, Japan.
Ryoichi IshikawaDepartment of Respiratory Medicine, Japanese Red Cross Osaka Hospital, Osaka City, Japan.
Erika NakaiDepartment of Respiratory Medicine, Japanese Red Cross Osaka Hospital, Osaka City, Japan.
Kenta NishiDepartment of Respiratory Medicine, Japanese Red Cross Osaka Hospital, Osaka City, Japan.
Chie YoshimuraDepartment of Respiratory Medicine, Japanese Red Cross Osaka Hospital, Osaka City, Japan.
Yasuo NishizakaDepartment of Respiratory Medicine, Japanese Red Cross Osaka Hospital, Osaka City, Japan.
Osaka Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune checkpoint inhibitors (ICIs) have been used to treat lung cancer. Several types of ICI-related interstitial lung diseases have been reported, including organizing pneumonia, non-specific interstitial pneumonia, and diffuse alveolar damage. However, pembrolizumab-associated bronchiolitis requiring treatment for persistent cough has not yet been reported. Here, we describe a patient who developed dry cough while being treated with pembrolizumab for lung adenocarcinoma. Radiography and lung biopsy findings indicated bronchiolitis. His cough improved after the discontinuation of pembrolizumab and treatment with erythromycin, an inhaled corticosteroid, a long-acting muscarinic antagonist, and a long-acting β

Indexed as

BronchiolitisImmune checkpoint inhibitors-related lung diseaseInhaled corticosteroidLong-acting muscarinic antagonistLong-acting β2 agonistLung cancer

Identifiers

PMID31198678
PMCPMC6557744
OpenAlexW2947576021

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.