Evidence map›Paper›PMID 31198525›Full record

ArticleMolecular autism2019

CYFIP1 overexpression increases fear response in mice but does not affect social or repetitive behavioral phenotypes.

Catherine Fricano-Kugler, Aaron Gordon, Grace Shin, Kun Gao, Jade Nguyen, Jamee Berg, Mary Starks, Daniel H Geschwind

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular autism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Overexpression of the autism candidate geneFrontiers in cellular neuroscience · 2023
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Cyfip1 Regulates SynGAP1 at Hippocampal Synapses.Frontiers in synaptic neuroscience · 2020
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Catherine Fricano-Kugler1Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 USA.
Aaron Gordon2Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA USA.
Grace Shin1Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 USA.
Kun Gao2Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA USA.
Jade Nguyen1Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 USA.
Jamee Berg1Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 USA.
Mary Starks2Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA USA.
Daniel H Geschwind3Program in Neurobehavioral Genetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 USA.ORCID 0000-0003-2896-3450
University of California, Los Angeles · US

Funding

1/2 Cross modal integration of molecular and physiological networks in ASDU01MH115746 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GESCHWIND, DANIEL H, MEHTA, MAYANK R · 2017 to 2021
$5.3M
NIMH NIH HHS U01 MH115746
6 · The paper itself

Abstract

Background: CYFIP1, a protein that interacts with FMRP and regulates protein synthesis and actin dynamics, is overexpressed in Dup15q syndrome as well as autism spectrum disorder (ASD). While Methods: We developed and validated a mouse model of human Results: Extensive behavioral testing in Conclusion: Overall, this research identifies the behavioral and molecular consequences of

Indexed as

Behavior, AnimalFearSocial BehaviorAdaptor Proteins, Signal TransducingAnimalsAnxietyAutism Spectrum DisorderBasolateral Nuclear ComplexCytoskeletonGABAergic NeuronsHumansIntellectual DisabilityInterneuronsLearningMemory DisordersMice, Inbred C57BLAdaptor Proteins, Signal TransducingCYFIP1 protein, humanAutism spectrum disorder (ASD)CYFIP1Dup15qFear conditioningMouse behaviorNeurodevelopmental disordersRNA sequencing

Identifiers

PMID31198525
PMCPMC6555997
OpenAlexW2948319532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.