Evidence map›Paper›PMID 31198491›Full record

ArticleOxidative medicine and cellular longevity2019

A Fragment of Apolipoprotein E4 Leads to the Downregulation of a CXorf56 Homologue, a Novel ER-Associated Protein, and Activation of BV2 Microglial Cells.

Tanner B Pollock, Jacob M Mack, Ryan J Day, Noail F Isho, Raquel J Brown, Alexandra E Oxford, Brad E Morrison, Eric J Hayden, Troy T Rohn

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Tanner B PollockDepartment of Biological Sciences, Boise State University, Science/Nursing Building, Room 228, Boise, Idaho 83725, USA.
Jacob M MackDepartment of Biological Sciences, Boise State University, Science/Nursing Building, Room 228, Boise, Idaho 83725, USA.
Ryan J DayUniversity of Washington, School of Medicine, Seattle, WA 98195, USA.
Noail F IshoDepartment of Biological Sciences, Boise State University, Science/Nursing Building, Room 228, Boise, Idaho 83725, USA.
Raquel J BrownDepartment of Biological Sciences, Boise State University, Science/Nursing Building, Room 228, Boise, Idaho 83725, USA.
Alexandra E OxfordDepartment of Biological Sciences, Boise State University, Science/Nursing Building, Room 228, Boise, Idaho 83725, USA.
Brad E MorrisonDepartment of Biological Sciences, Boise State University, Science/Nursing Building, Room 228, Boise, Idaho 83725, USA.
Eric J HaydenDepartment of Biological Sciences, Boise State University, Science/Nursing Building, Room 228, Boise, Idaho 83725, USA.
Troy T RohnDepartment of Biological Sciences, Boise State University, Science/Nursing Building, Room 228, Boise, Idaho 83725, USA.ORCID 0000-0002-8406-1956
Boise State University · USUniversity of Washington · US

Funding

Women's health: interplay of maternal diet and key demographics on neurological health in the rural frontier and remote WestP20GM103408 · NIGMS · UNIVERSITY OF IDAHO · PI Scott A Minnich · 2012 to 2026
$59.8M
UNDERGRADUATE COLLEGE OUTREACH PROGRAMP20RR016454 · NCRR · UNIVERSITY OF IDAHO · PI CHASE, JENNIFER R · 2001 to 2011
$35.3M
VPS35 D620N inhibits autophagy through disrupted hyaluronic acid-CD44 signalingP20GM109095 · NIGMS · BOISE STATE UNIVERSITY · PI OXFORD, JULIA THOM · 2014 to 2023
$22.7M
Nuclear Localization of an Amino-Terminal Fragment of Apolipoprotein E4 in the Alzheimer's Disease BrainR15AG042781 · NIA · BOISE STATE UNIVERSITY · PI ROHN, TROY T · 2013 to 2022
$1.1M
NCRR NIH HHS P20 RR016454NIA NIH HHS R15 AG042781NIGMS NIH HHS P20 GM103408NIGMS NIH HHS P20 GM109095
6 · The paper itself

Abstract

Despite the fact that harboring the apolipoprotein E4 (

Indexed as

Gene Expression RegulationAnimalsApolipoprotein E4AstrocytesCells, CulturedCytokinesHumansMiceMicrogliaPeptide FragmentsTranscription FactorsApolipoprotein E4CytokinesMamld1 protein, mousePeptide FragmentsTranscription Factors

Identifiers

PMID31198491
PMCPMC6526552
OpenAlexW2943424764

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.