Evidence map›Paper›PMID 31198475›Full record

ArticleDisease markers2019

DNA Methylation Profiles and Their Diagnostic Utility in BC.

Ming Shan, Lei Zhang, Yang Liu, Chunyang Gao, Wenli Kang, Weiwei Yang, Yan He, Guoqiang Zhang

Open access · hybridAbstract readEvaluation Study
In one paragraph

Article in Disease markers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Methylation inCells · 2020
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ming ShanDepartment of BC Surgery, Harbin Medical University Cancer Hospital, Harbin, China.
Lei ZhangDepartment of Pathology, Harbin Medical University, Harbin, China.
Yang LiuDepartment of BC Surgery, Harbin Medical University Cancer Hospital, Harbin, China.ORCID 0000-0003-2056-8413
Chunyang GaoDepartment of Pathology, Harbin Medical University, Harbin, China.ORCID 0000-0001-6431-9609
Wenli KangDepartment of Oncology, General Hospital of HeiLongjiang Province Land Reclamation Headquarter, Harbin, China.ORCID 0000-0002-5976-4190
Weiwei YangDepartment of Pathology, Harbin Medical University, Harbin, China.
Yan HeDepartment of Pathology, Harbin Medical University, Harbin, China.ORCID 0000-0001-8074-0313
Guoqiang ZhangDepartment of BC Surgery, Harbin Medical University Cancer Hospital, Harbin, China.ORCID 0000-0003-0771-7533
Harbin Medical University · CNHeilongjiang Academy of Land Reclamation Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomarkers, including DNA methylation, have shown a great potential for use in personalized medicine for BC and especially for the diagnosis of BC in developing countries. According to the bisulfite sequencing PCR in twelve specimens (BC and matched normal tissues), nine genetic probes were designed to detect the frequency of methylation of the promoters in a total of 302 paired cases of BC and matched normal breast tissues. Finally, a total of 900 serum samples were used to validate the use of these methylation biomarkers for clinical diagnosis of BC. A high frequency of promoter methylation of

Indexed as

DNA MethylationAdultBiomarkers, TumorFemaleHomeodomain ProteinsHumansMaleMiddle AgedMutL Protein Homolog 1Promoter Regions, GeneticTranscription FactorsTumor Suppressor ProteinsUrinary Bladder NeoplasmsWnt-5a ProteinBiomarkers, TumorHomeodomain ProteinsHOXD13 protein, humanMLH1 protein, humanMutL Protein Homolog 1RASSF1 protein, humanTranscription FactorsTumor Suppressor ProteinsWnt-5a ProteinWNT5A protein, human

Identifiers

PMID31198475
PMCPMC6526564
OpenAlexW2943721408

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.