Evidence map›Paper›PMID 31198474›Full record

ArticleDisease markers2019

Coding Region Mutation Screening in Optineurin in Chinese Normal-Tension Glaucoma Patients.

Jing Na He, Shiyao Lu, Li Jia Chen, Pancy Oi Sin Tam, Bi Ning Zhang, Christopher Kai Shun Leung, Chi Pui Pang, Clement Chee Yung Tham, Wai Kit Chu

Open access · hybridAbstract read
In one paragraph

Article in Disease markers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Optineurin in ocular herpes infection.Experimental eye research · 2022
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jing Na HeDepartment of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong.
Shiyao LuDepartment of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong.
Li Jia ChenDepartment of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong.ORCID 0000-0003-3500-5840
Pancy Oi Sin TamDepartment of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong.
Bi Ning ZhangDepartment of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong.
Christopher Kai Shun LeungDepartment of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong.ORCID 0000-0003-4862-777X
Chi Pui PangDepartment of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong.
Clement Chee Yung ThamDepartment of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong.
Wai Kit ChuDepartment of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong.ORCID 0000-0003-2903-3247
Chinese University of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo study the roles of sequence alterations in the optineurin (

methodsGenomic DNA was extracted from 190 NTG patients and 201 control subjects. The thirteen exons of

resultsSeven sequence changes in

conclusionsThis study confirmed the association of the OPTN T34T variant with NTG, suggesting that

Indexed as

Mutation, MissenseCell Cycle ProteinsChinaHeterozygoteHumansLow Tension GlaucomaMembrane Transport ProteinsPolymorphism, Single NucleotideTranscription Factor TFIIIACell Cycle ProteinsMembrane Transport ProteinsOPTN protein, humanTranscription Factor TFIIIA

Identifiers

PMID31198474
PMCPMC6526575
OpenAlexW2942938698

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.