ArticleJournal of pharmacy & bioallied sciences2019
Analysis of Ki-67 Expression in Oral Premalignant Lesions and Normal Oral Mucosa: An Immunohistochemical Study.
Article in Journal of pharmacy & bioallied sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors at 1 institution in 1 country.
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Abstract
aimThis study aimed to evaluate the Ki-67 expression in oral premalignant lesions and normal oral mucosa. MATERIALS AND
methodsThe cases were selected on the basis of the details obtained from the patients. A total of 45 specimens were divided into three groups: Group 1 (normal mucosa), Group 2 (clinically and histologically diagnosed as oral lichen planus), and Group 3 (clinically and histologically diagnosed as leukoplakia). Specimens were prepared and the slides for Ki-67 were observed under light microscope with a magnification of ×400. The tissue samples were thoroughly examined, and the pattern of expression was analyzed semiquantitatively by counting the number of positive cells.
resultsThe mean positive cell count of normal mucosa was 23.20 ± 2.89, of oral lichen planus was 42.82 ± 2.65, and of leukoplakia was 82.14 ± 3.10. There was a statistically significant difference of expression observed between the groups (
conclusionKi-67 is an easily applicable marker of cell proliferation whose expression correlates well with the disease progression.
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