Evidence map›Paper›PMID 31198003›Full record

ArticleZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery2019

[Influence of endoplasmic reticulum stress on smoking-induced nucleus pulposus cells apoptosis and inflammatory response].

Xiaozhong Hou, Linfei Xu, Weiwei Yi, Yanyang Chen, Jieliang Shen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 74% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 0 citations in OpenAlex.

  1. [Research progress of hydrogel used for regeneration of nucleus pulposus in intervertebral disc degeneration].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2020
    Review
  2. [Research progress on the role of adipokines in intervertebral disc degeneration].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xiaozhong HouDepartment of Orthopedics, Henan Provincial Hospital, Zhengzhou Henan, 450000, P.R.China.
Linfei XuDepartment of Orthopedics, Henan Provincial Chest Hospital, Zhengzhou Henan, 450003, P.R.China;Department of Orthopedics, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400042, P.R.China.
Weiwei YiDepartment of Orthopedics, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400042, P.R.China.
Yanyang ChenDepartment of Orthopedics, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400042, P.R.China.
Jieliang ShenDepartment of Orthopedics, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400042, P.R.China.franklinspine@163.com.
The Affiliated Yongchuan Hospital of Chongqing Medical University · CNHenan Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the influence of endoplasmic reticulum stress (ERS) on smoking-induced nucleus pulposus cells apoptosis and inflammatory response.

methodsBetween October 2016 and October 2018, 25 patients with cervical disc herniation receiving discectomy were collected and divided into smoking group (14 cases) and non-smoking group (11 cases). The baseline data of age, gender, herniated segment, and Pfirrmann grading showed no significant difference between the two groups (

resultsThe nucleus pulposus tissue observation showed that the cell apoptotic rate and the expressions of apoptosis-related proteins (Caspase-3 and PARP) were obviously higher in smoking group than in non-smoking group (

conclusionSomking can stimulate cell apoptosis and inflammatory response in nucleus pulposus cells via ESR pathway. Suppressing ESR may be a novel target to suspend smoking-induced intervertebral disc degeneration.

Indexed as

Endoplasmic Reticulum StressInflammationIntervertebral Disc DegenerationNucleus PulposusSmokingApoptosisEndoplasmic Reticulum Chaperone BiPHumansInterleukin-1betaEndoplasmic Reticulum Chaperone BiPHSPA5 protein, humanInterleukin-1betacell apoptosisendoplasmic reticulum stressinflammatory responseintervertebral disc degenerationSmoking

Identifiers

PMID31198003
PMCPMC8355760
OpenAlexW3025101492

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.