Evidence map›Paper›PMID 31197995›Full record

ArticleZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery2019

[Effect of stromal cell-derived factor 1α/cysteine X cysteine receptor 4 signaling pathway on axial stress stimulation promoting bone regeneration].

Jianbiao Lin, Guofeng Huang, Wenbin Ye, Cong Zhu, Jianting Gao, Guojun Liu, Huixiang Jiang, Benwen Wu, Zhenqi Ding

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jianbiao LinDepartment of Orthopedics, the Affiliated Dongnan Hospital of Xiamen University, the 909th Hospital, Zhangzhou Fujian, 363099, P.R.China.
Guofeng HuangDepartment of Orthopedics, the Affiliated Dongnan Hospital of Xiamen University, the 909th Hospital, Zhangzhou Fujian, 363099, P.R.China.huangguofeng175@163.com.
Wenbin YeDepartment of Orthopedics, the Affiliated Dongnan Hospital of Xiamen University, the 909th Hospital, Zhangzhou Fujian, 363099, P.R.China.
Cong ZhuSchool of Medicine, Xiamen University, Xiamen Fujian, 361102, P.R.China.
Jianting GaoDepartment of Orthopedics, the Affiliated Dongnan Hospital of Xiamen University, the 909th Hospital, Zhangzhou Fujian, 363099, P.R.China.
Guojun LiuDepartment of Orthopedics, the Affiliated Dongnan Hospital of Xiamen University, the 909th Hospital, Zhangzhou Fujian, 363099, P.R.China.
Huixiang JiangSchool of Medicine, Xiamen University, Xiamen Fujian, 361102, P.R.China.
Benwen WuDepartment of Orthopedics, the Affiliated Dongnan Hospital of Xiamen University, the 909th Hospital, Zhangzhou Fujian, 363099, P.R.China.
Zhenqi DingDepartment of Orthopedics, the Affiliated Dongnan Hospital of Xiamen University, the 909th Hospital, Zhangzhou Fujian, 363099, P.R.China.dzqi@xmu.edu.cn.
Xiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo observe the change of stromal cell-derived factor 1α/cysteine X cysteine receptor 4 (SDF-1α/CXCR4) signaling pathway during the process of axial stress stimulation promoting bone regeneration, and to further explore its mechanism.

methodsA total of 72 male New Zealand white rabbits were selected to prepare the single cortical bone defect in diameter of 8 mm at the proximal end of the right tibia that repaired with deproteinized cancellous bone. All models were randomly divided into 3 groups (

resultsX-ray film showed that the Lane-Sandhu scores of bone healing in group B were significantly higher than those in groups A and C at 4, 8, and 12 weeks after operation (

conclusionAxial stress stimulation can promote the expression of SDF-1α in bone defect tissue, activate and regulate the CXCR4 signal collected by marrow mesenchymal stem cells, and accelerate bone regeneration in bone defect area.

Indexed as

Bone RegenerationChemokine CXCL12CysteineAnimalsBiomechanical PhenomenaMaleRabbitsReceptors, CXCR4Signal TransductionVascular Endothelial Growth Factor AChemokine CXCL12CysteineReceptors, CXCR4Vascular Endothelial Growth Factor Aaxial stressbone marrow mesenchymal stem cellsbone regenerationcysteine X cysteine receptor 4rabbitStromal cell-derived factor 1α

Identifiers

PMID31197995
PMCPMC8355772
OpenAlexW3003326888

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.