Evidence map›Paper›PMID 31197744›Full record

ArticleCellular and molecular neurobiology2019

Regulation of the Serotonergic System by Kainate in the Avian Retina.

Adelaide da Conceição Fonseca Passos, Anderson Manoel Herculano, Karen R H M Oliveira, Silene Maria A de Lima, Fernando A F Rocha, Hércules Rezende Freitas, Luzia da Silva Sampaio, Danniel Pereira Figueiredo, Karin da Costa Calaza, Ricardo Augusto de Melo Reis and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Adelaide da Conceição Fonseca PassosLaboratório de Neuroquímica Molecular e Celular, Instituto de Ciências Biológicas, Universidade Federal do Pará, Campus Universitário do Guamá, Rua Augusto Correa 01, Belém-PA, 66075-110, Brazil.
Anderson Manoel HerculanoLaboratório de Neuroquímica Molecular e Celular, Instituto de Ciências Biológicas, Universidade Federal do Pará, Campus Universitário do Guamá, Rua Augusto Correa 01, Belém-PA, 66075-110, Brazil.
Karen R H M OliveiraLaboratório de Neuroquímica Molecular e Celular, Instituto de Ciências Biológicas, Universidade Federal do Pará, Campus Universitário do Guamá, Rua Augusto Correa 01, Belém-PA, 66075-110, Brazil.
Silene Maria A de LimaLab de Neurobiologia, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém-PA, Brazil.
Fernando A F RochaLab de Neurobiologia, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém-PA, Brazil.
Hércules Rezende FreitasLaboratório de Neuroquímica, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio De Janeiro-RJ, Brazil.
Luzia da Silva SampaioLaboratório de Neuroquímica, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio De Janeiro-RJ, Brazil.
Danniel Pereira FigueiredoLaboratório de Neuroquímica, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio De Janeiro-RJ, Brazil.
Karin da Costa CalazaLab Neurobiologia da Retina, Programa de Pós-graduação em Neurociências, Universidade Federal Fluminense, Rio De Janeiro-RJ, Brazil.
Ricardo Augusto de Melo ReisLaboratório de Neuroquímica, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio De Janeiro-RJ, Brazil.
José Luiz Martins do NascimentoLaboratório de Neuroquímica Molecular e Celular, Instituto de Ciências Biológicas, Universidade Federal do Pará, Campus Universitário do Guamá, Rua Augusto Correa 01, Belém-PA, 66075-110, Brazil. jlmn@ufpa.br.
Universidade Federal do Pará · BRUniversidade Federal do Rio de Janeiro · BRUniversidade Federal Fluminense · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serotonin (5-HT) has been recognized as a neurotransmitter in the vertebrate retina, restricted mainly to amacrine and bipolar cells. It is involved with synaptic processing and possibly as a mitogenic factor. We confirm that chick retina amacrine and bipolar cells are, respectively, heavily and faintly immunolabeled for 5-HT. Amacrine serotonergic cells also co-express tyrosine hydroxylase (TH), a marker of dopaminergic cells in the retina. Previous reports demonstrated that serotonin transport can be modulated by neurotransmitter receptor activation. As 5-HT is diffusely released as a neuromodulator and co-localized with other transmitters, we evaluated if 5-HT uptake or release is modulated by several mediators in the avian retina. The role of different glutamate receptors on serotonin transport and release in vitro and in vivo was also studied. We show that L-glutamate induces an inhibitory effect on [

Indexed as

AnimalsCalciumCells, CulturedChick EmbryoExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsKainic AcidKainic Acid ReceptorsNeurotransmitter AgentsReceptors, GlutamateRetinaRetinal NeuronsSerotoninTritiumCalciumExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsKainic AcidKainic Acid ReceptorsNeurotransmitter AgentsReceptors, GlutamateSerotoninTritiumGlutamate receptorsKainateRetinaSerotonin

Identifiers

PMID31197744
PMCPMC11457822
OpenAlexW2952572773

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.