Evidence map›Paper›PMID 31197600›Full record

ArticleJournal of molecular modeling2019

Discovery of SBF1 as an allosteric inhibitor targeting the PIF-pocket of 3-phosphoinositide-dependent protein kinase-1.

Wei Liu, Pengfei Li, Ye Mei

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular modeling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Wei LiuState Key Laboratory of Precision Spectroscopy, School of Physics and Materials Science, East China Normal University, Shanghai, 200062, China.
Pengfei LiState Key Laboratory of Precision Spectroscopy, School of Physics and Materials Science, East China Normal University, Shanghai, 200062, China.
Ye MeiState Key Laboratory of Precision Spectroscopy, School of Physics and Materials Science, East China Normal University, Shanghai, 200062, China. ymei@phy.ecnu.edu.cn.ORCID http://orcid.org/0000-0002-3953-8508
East China Normal University · CNShanxi University · CN

Funding

Ministry of Science and Technology of China 2016YFA0501700National Natural Science Foundation of China 21773066
6 · The paper itself

Abstract

3-phosphoinositide-dependent protein kinase-1 (PDK1) plays a crucial role in the signal transduction of massive growth-related protein kinases. In this work, a computational study has been performed to investigate the binding pose of the hydrolyzed product of SBF1 (SBF1

Indexed as

Allosteric SiteBinding SitesQuantitative Structure-Activity Relationship3-Phosphoinositide-Dependent Protein KinasesAlgorithmsAllosteric RegulationHumansIntracellular Signaling Peptides and ProteinsMolecular ConformationMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructureProtein Binding3-Phosphoinositide-Dependent Protein KinasesIntracellular Signaling Peptides and ProteinsPDPK1 protein, humanSBF1 protein, human3-phosphoinositide-dependent protein kinase-1AllostericFree energySBF1

Identifiers

PMID31197600
OpenAlexW2953300734

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.