ArticleMikrochimica acta2019
Fluorometric and resonance Rayleigh scattering dual-mode bioprobe for determination of the activity of alkaline phosphatase based on the use of CoOOH nanoflakes and cobalt(II)-dependent DNAzyme-assisted amplification.
Article in Mikrochimica acta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 17 citations in OpenAlex.
- Portable smartphone device-based multi-signal sensing system for on-site and visual determination of alkaline phosphatase in human serum.Mikrochimica acta · 2021Article
- A smartphone-based platform for point-of-use determination of alkaline phosphatase as an indicator of water eutrophication.Mikrochimica acta · 2020Article
- A Highly Sensitive SERS and RRS Coupled Di-Mode Method for CO Detection Using Nanogolds as Catalysts and Bifunctional Probes.Nanomaterials (Basel, Switzerland) · 2020Article
- Gold and silver nanoparticles in resonance Rayleigh scattering techniques for chemical sensing and biosensing: a review.Mikrochimica acta · 2019Review
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
The authors describe a fluorometric and resonance Rayleigh scattering dual-mode scheme for detection of the activity and inhibition of alkaline phosphatase (ALP). The method utilizes (a) CoOOH nanoflakes, which have high resonance Rayleigh scattering activity and can strongly adsorb ssDNA, and (b) Co(II)-dependent DNAzyme assisted signal amplification. ALP specifically catalyzes the hydrolysis of ascorbic acid-2-phosphate to produce ascorbic acid which reduces CoOOH nanoflakes to Co(II) ion. The Co(II)-dependent DNAzyme is then activated by Co(II) ion, and this results in the cleavage of a substrate labeled with both a fluorophore and a quencher. Following hydrolysis, fluorophore and quencher become separated and the fluorescence measured at excitation/emission wavelengths of 490/518 nm recovers, while the RRS signal at 405 nm decreases. The method works on the 0.2 to 2000 U L
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