Evidence map›Paper›PMID 31197506›Full record

Observational studyEuropean journal of nutrition2020

Effects of a formula with a probiotic Bifidobacterium lactis Supplement on the gut microbiota of low birth weight infants.

Cheng Chi, Yong Xue, Ruixia Liu, Yanxin Wang, Na Lv, Huihui Zeng, Nicholas Buys, Baoli Zhu, Jing Sun, Chenghong Yin

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in European journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
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  4. Article
  5. Complete Genome Sequence of Bifidobacterium animalis subsp.Microbiology resource announcements · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Cheng ChiDepartment of Internal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, 100026, China.ORCID http://orcid.org/0000-0002-0097-2438
Yong XueCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Ruixia LiuDepartment of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, 100026, China.
Yanxin WangDepartment of Internal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, 100026, China.
Na LvCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Science, Beijing, 100101, China.
Huihui ZengDepartment of Neonatology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, 100026, China.
Nicholas BuysMenzies Health Institute Queensland, Griffith University, Gold Coast, QLD, 4222, Australia.
Baoli ZhuCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Science, Beijing, 100101, China. zhubaoli@im.ac.cn.
Jing SunSchool of Medicine, Griffith University, Gold Coast, QLD, 4222, Australia. j.sun@griffith.edu.au.
Chenghong YinDepartment of Internal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, 100026, China. modscn@126.com.
Capital Medical University · CNGriffith University · AUInstitute of Microbiology · CNChina Agricultural University · CN

Funding

Beijing Natural Science Foundation S160003
6 · The paper itself

Abstract

purposeLow birth weight (LBW) infants have a less diverse gut microbiota, enriched in potential pathogens, which places them at high risk of systemic inflammation diseases. This study aimed to identify the differences in gut bacterial community structure between LBW infants who received probiotics and LBW infants who did not receive probiotics.

methodsForty-one infants were allocated to the non-probiotic group (N group) and 56 infants to the probiotic group (P group), according to whether the formula they received contained a probiotic Bifidobacterium lactis. Gut bacterial composition was identified with sequencing of the 16S rRNA gene in fecal samples collected at 14 days after birth.

resultsThere was no significant difference between the alpha diversity of the two groups, while the beta diversity was significantly different (p < 0.05). Our results showed that Bifidobacterium and Lactobacillus (both p < 0.05) were enriched in the P group, while Veillonella, Dolosigranulum and Clostridium sensu stricto 1 (all p < 0.05) were enriched in the N group. Predicted metagenome function analysis revealed enhancement of fatty acids, peroxisome, starch, alanine, tyrosine and peroxisome pathways in the P group, and enhancement of plant pathogen, Salmonella and Helicobacter pylori infection pathways in the N group.

conclusionsProbiotic supplement in formula may affect the composition, stability and function of LBW infants' gut microbiota. LBW infants who receive probiotic intervention may benefit from gut microbiota that contains more beneficial bacteria.

Indexed as

Infant FormulaBifidobacterium animalisDietary SupplementsFecesFemaleGastrointestinal MicrobiomeHumansInfant, Low Birth WeightInfant, NewbornMaleProbioticsGut microbiotaLow birth weight infantMetagenome function analysisProbiotics

Identifiers

PMID31197506
OpenAlexW2952552088

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.