ReviewAnnals of intensive care2019
Formal guidelines: management of acute respiratory distress syndrome.
Review in Annals of intensive care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 348 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safety and Efficacy of a Strategy Extending Duration of Prone Position in COVID-19-related ARDS Patients. a Retrospective Monocentric Observational Study
An Observational Study of the Relationship Between Pressure-volume Curves and Recruitability of the Lung in Mechanically Ventilated Critically Ill Patients With Respiratory Failure
Effects on Biotrauma of Combining Routine CURArization With Prone Positioning During Adult Acute Respiratory Distress Syndrome
Who cites it
348 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- [S3 guideline on sepsis-prevention, diagnosis, therapy, and follow-up care-update 2025].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025Guideline
- Extracorporeal membrane oxygenation technology for adults: an evidence mapping based on systematic reviews.European journal of medical research · 2024Pooled it
- Effects of prone positioning on ARDS outcomes of trauma and surgical patients: a systematic review and meta-analysis.BMC pulmonary medicine · 2023Pooled it
- Early intubation and clinical outcomes in patients with severe COVID-19: a systematic review and meta-analysis.European journal of medical research · 2022Pooled it
- Early spontaneous breathing for acute respiratory distress syndrome in individuals with COVID-19.The Cochrane database of systematic reviews · 2022Pooled it
- Usefulness of low tidal volume ventilation strategy for patients with acute respiratory distress syndrome: a systematic review and meta-analysis.Scientific reports · 2022Pooled it
- Awake prone positioning for non-intubated patients with COVID-19-related acute hypoxaemic respiratory failure: a systematic review and meta-analysis.The Lancet. Respiratory medicine · 2022Pooled it
- Evolution of Acute Respiratory Distress Syndrome in Emergency and Critical Care: Therapeutic Management before and during the Pandemic Situation.Medicina (Kaunas, Lithuania) · 2022Pooled it
- The role of acute hypercapnia on mortality and short-term physiology in patients mechanically ventilated for ARDS: a systematic review and meta-analysis.Intensive care medicine · 2022Pooled it
- Innovative nitric oxide delivery technology for postoperative pulmonary hypertension in congenital heart disease patients: a clinical trial.BMC cardiovascular disorders · 2025Trial
- Optimal Prone Position Duration in Patients With ARDS Due to COVID-19: The Omelette Pilot Trial.Respiratory care · 2024Trial
- Timing of intubation and ICU mortality in COVID-19 patients: a retrospective analysis of 4198 critically ill patients during the first and second waves.BMC anesthesiology · 2023Trial
- Vitamin D Supplementation and Clinical Outcomes in Severe COVID-19 Patients-Randomized Controlled Trial.Nutrients · 2023Trial
- High- Versus Low-Dose Dexamethasone for the Treatment of COVID-19-Related Acute Respiratory Distress Syndrome: A Multicenter, Randomized Open-Label Clinical Trial.Journal of intensive care medicine · 2022Trial
- Factors for success of awake prone positioning in patients with COVID-19-induced acute hypoxemic respiratory failure: analysis of a randomized controlled trial.Critical care (London, England) · 2022Trial
- Mechanical ventilation in acute brain injury.Breathe (Sheffield, England) · 2026Review
- Inhalable carrier-free self-assembled leonurine-ursolic acid nanoaggregates ameliorate acute lung injury by suppressing TLR4/MyD88-NET axis.Materials today. Bio · 2026Article
- Volatile anesthetic sedation in acute respiratory distress syndrome.Intensive care medicine · 2026Review
- Dissociation between airway and transpulmonary pressures during external chest wall restriction: a prospective self-controlled physiological study.Journal of thoracic disease · 2026Article
- Standardized low-flow ventilation with PEEP maintenance during bronchoscopy in mechanically ventilated ICU patients: a pilot trial.Journal of intensive care · 2026Article
288 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fifteen recommendations and a therapeutic algorithm regarding the management of acute respiratory distress syndrome (ARDS) at the early phase in adults are proposed. The Grade of Recommendation Assessment, Development and Evaluation (GRADE) methodology has been followed. Four recommendations (low tidal volume, plateau pressure limitation, no oscillatory ventilation, and prone position) had a high level of proof (GRADE 1 + or 1 -); four (high positive end-expiratory pressure [PEEP] in moderate and severe ARDS, muscle relaxants, recruitment maneuvers, and venovenous extracorporeal membrane oxygenation [ECMO]) a low level of proof (GRADE 2 + or 2 -); seven (surveillance, tidal volume for non ARDS mechanically ventilated patients, tidal volume limitation in the presence of low plateau pressure, PEEP > 5 cmH2O, high PEEP in the absence of deleterious effect, pressure mode allowing spontaneous ventilation after the acute phase, and nitric oxide) corresponded to a level of proof that did not allow use of the GRADE classification and were expert opinions. Lastly, for three aspects of ARDS management (driving pressure, early spontaneous ventilation, and extracorporeal carbon dioxide removal), the experts concluded that no sound recommendation was possible given current knowledge. The recommendations and the therapeutic algorithm were approved by the experts with strong agreement.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.