Evidence map›Paper›PMID 31197413›Full record

Trial reportNeuroradiology2019

Optimal 4DFlow MR sequence parameters for the assessment of internal carotid artery stenosis: a simulation study.

Joseph Benzakoun, Pauline Roca, David Calvet, Olivier Naggara, Stéphanie Lion, Marie-Pierre Gobin-Metteil, Sylvain Charron, Victoria Cavero, Jean-François Meder, Myriam Edjlali and 1 more

Abstract readClinical TrialComparative Study
PubMed Publisher
In one paragraph

Trial report in Neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Joseph BenzakounService d'Imagerie Morphologique et Fonctionnelle, GHU Paris, 1 rue Cabanis, 75014, Paris, France. benzakoun.joseph@gmail.com.ORCID http://orcid.org/0000-0002-0733-0104
Pauline RocaService d'Imagerie Morphologique et Fonctionnelle, GHU Paris, 1 rue Cabanis, 75014, Paris, France.
David CalvetUniversité Paris Descartes, 12 Rue de l'École de Médecine, 75006 Paris, France. INSERM 1266, 102-108 rue de la Santé, 75014, Paris, France.
Olivier NaggaraService d'Imagerie Morphologique et Fonctionnelle, GHU Paris, 1 rue Cabanis, 75014, Paris, France.
Stéphanie LionService d'Imagerie Morphologique et Fonctionnelle, GHU Paris, 1 rue Cabanis, 75014, Paris, France.
Marie-Pierre Gobin-MetteilService d'Imagerie Morphologique et Fonctionnelle, GHU Paris, 1 rue Cabanis, 75014, Paris, France.
Sylvain CharronService d'Imagerie Morphologique et Fonctionnelle, GHU Paris, 1 rue Cabanis, 75014, Paris, France.
Victoria CaveroGE Healthcare, Buc, France.
Jean-François MederService d'Imagerie Morphologique et Fonctionnelle, GHU Paris, 1 rue Cabanis, 75014, Paris, France.
Myriam Edjlali *Service d'Imagerie Morphologique et Fonctionnelle, GHU Paris, 1 rue Cabanis, 75014, Paris, France.
Catherine Oppenheim *Service d'Imagerie Morphologique et Fonctionnelle, GHU Paris, 1 rue Cabanis, 75014, Paris, France.

Funding

General Electrics Healthcare N/A
6 · The paper itself

Abstract

purposeIn patients with ICA stenosis, increased peak systolic velocity is a marker of stenosis at risk of ischemic stroke. 4DFlow MRI is a reproducible technique to evaluate velocities in ICA stenosis, although it seems to underestimate velocities as compared with Doppler ultrasonography. The purpose of our study was to confirm that velocities were underestimated on a new set of data acquired with a clinical 4DFlow sequence, and to devise optimal acquisition parameters for ICA stenosis exploration based on a numerical simulation.

methodsAfter review board approval, 15 healthy controls and 12 patients presenting ICA stenosis were explored with Doppler ultrasonography and 4DFlow MRI. We created a 2-dimensional simulation of ICA stenosis and its corresponding 4DFlow acquisition, and compared its mean peak systolic velocity underestimation to real MRI and Doppler. We then simulated the acquisition for voxel size ranging from 0.5 to 1.25 mm and number of phases per cardiac cycle ranging from 10 to 25.

resultsOn acquired data, 4DFlow MR underestimated peak systolic velocities (mean difference between Doppler and 4DFlow: - 35 cm/s), especially high velocities. With spatial and temporal resolutions equivalent to MR acquisition, our simulation yielded similar underestimation (mean difference: - 31 cm/s, P = 0.30). Simulations showed that 0.7-mm resolution and 20 phases per cardiac cycle would be necessary to record peak systolic velocities up to 250 cm/s.

conclusionHigher spatial resolution can provide accurate peak systolic velocities measurement with 4DFlow MRI, thus allowing better ICA stenosis assessment. Further studies are needed to validate the proposed parameters.

Indexed as

AdultAgedBlood Flow VelocityCarotid Artery, InternalCarotid StenosisComputer SimulationFemaleHemodynamicsHumansImaging, Three-DimensionalMagnetic Resonance AngiographyMaleMiddle AgedReference ValuesRisk FactorsSensitivity and SpecificityCarotid arteryCarotid stenosisMagnetic resonance angiographyStroke

Identifiers

PMID31197413

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.