Evidence map›Paper›PMID 31197225›Full record

ArticleScientific reports2019

Antigenicity and immune correlate assessment of seven Plasmodium falciparum antigens in a longitudinal infant cohort from northern Ghana.

Kwadwo Asamoah Kusi, Joao Aguiar, Selassie Kumordjie, Felix Aggor, Jessica Bolton, Andrea Renner, Eric Kyei-Baafour, Naiki Puplampu, Maria Belmonte, Daniel Dodoo and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 2 countries.

Kwadwo Asamoah KusiImmunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana. akusi@noguchi.ug.edu.gh.ORCID http://orcid.org/0000-0001-5483-9985
Joao AguiarMalaria Department, Naval Medical Research Center, Silver Spring, MD, 20910, USA.
Selassie KumordjieImmunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
Felix AggorImmunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
Jessica BoltonMalaria Department, Naval Medical Research Center, Silver Spring, MD, 20910, USA.
Andrea RennerMalaria Department, Naval Medical Research Center, Silver Spring, MD, 20910, USA.
Eric Kyei-BaafourImmunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.ORCID http://orcid.org/0000-0001-6423-1885
Naiki PuplampuUS Naval Medical Research Unit No. 3, Ghana Detachment, Accra, Ghana.
Maria BelmonteMalaria Department, Naval Medical Research Center, Silver Spring, MD, 20910, USA.ORCID http://orcid.org/0000-0002-4103-6611
Daniel DodooImmunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
Ben Adu GyanImmunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
Michael Fokuo OforiImmunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
Abraham Rex OduroNavrongo Health Research Centre, Ghana Health Service, Navrongo, Ghana.
Frank AtugubaNavrongo Health Research Centre, Ghana Health Service, Navrongo, Ghana.
Kwadwo Ansah KoramEpidemiology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.ORCID http://orcid.org/0000-0003-4274-6516
Nehkonti AdamsUS Naval Medical Research Unit No. 3, Ghana Detachment, Accra, Ghana.
Andrew LetiziaUS Naval Medical Research Unit No. 3, Ghana Detachment, Accra, Ghana.
Eileen VillasanteMalaria Department, Naval Medical Research Center, Silver Spring, MD, 20910, USA.
Martha SedegahMalaria Department, Naval Medical Research Center, Silver Spring, MD, 20910, USA.
University of Ghana · GHNaval Medical Research Command · USNavrongo Health Research Centre · GHUnited States Department of the Navy · US

Funding

NIAID NIH HHS HHSN266200400016C
6 · The paper itself

Abstract

The current global malaria control and elimination agenda requires development of additional effective disease intervention tools. Discovery and characterization of relevant parasite antigens is important for the development of new diagnostics and transmission monitoring tools and for subunit vaccine development. This study assessed the natural antibody response profile of seven novel Plasmodium falciparum pre-erythrocytic antigens and their potential association with protection against clinical malaria. Antigen-specific antibody levels in plasma collected at six time points from a longitudinal cohort of one-to-five year old children resident in a seasonal malaria transmission area of northern Ghana were assessed by ELISA. Antibody levels were compared between parasite-positive and parasite-negative individuals and the association of antibody levels with malaria risk assessed using a regression model. Plasma antibody levels against five of the seven antigens were significantly higher in parasite-positive children compared to parasite-negative children, especially during low transmission periods. None of the antigen-specific antibodies showed an association with protection against clinical malaria. The study identified five of the seven antigens as markers of exposure to malaria, and these will have relevance for the development of disease diagnostic and monitoring tools. The vaccine potential of these antigens requires further assessment.

Indexed as

Antibodies, ProtozoanAntigens, ProtozoanChild, PreschoolCohort StudiesEpitopesGhanaHumansInfantLinear ModelsLongitudinal StudiesMalaria, FalciparumParasitemiaPlasmodium falciparumAntibodies, ProtozoanAntigens, ProtozoanEpitopes

Identifiers

PMID31197225
PMCPMC6565625
OpenAlexW2950457014

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.