ArticleNature communications2019
An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis.
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In one paragraph
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 5 of them syntheses that pooled it.
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63citing papers in PubMed, 5 pooled it
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Who cites it
63 citing papers in PubMed, 5 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Dietary and supplemental intake of vitamins C and E is associated with altered DNA methylation in an epigenome-wide association study meta-analysis.Epigenetics · 2023Pooled it
- Investigating causality in the association between DNA methylation and type 2 diabetes using bidirectional two-sample Mendelian randomisation.Diabetologia · 2023Pooled it
- Maternal Mediterranean diet in pregnancy and newborn DNA methylation: a meta-analysis in the PACE Consortium.Epigenetics · 2022Pooled it
- Multi-omics analysis identifies CpGs near G6PC2 mediating the effects of genetic variants on fasting glucose.Diabetologia · 2021Pooled it
- Identification, Heritability, and Relation With Gene Expression of Novel DNA Methylation Loci for Blood Pressure.Hypertension (Dallas, Tex. : 1979) · 2020Pooled it
- EpCAM aptamer modified carbon@manganese dioxide nanoflower for synergistic drug-nanozyme allergic rhinitis treatment.Materials today. Bio · 2026Article
- Acute Hyperinsulinemia during Hyperinsulinemic- Euglycemic Clamp Influences DNA Methylation and Gene Expression in Peripheral Blood Cells of Adult Men.Diabetes & metabolism journal · 2026Article
- Epigenome-wide association study of blood proteome in the Atherosclerosis Risk in Communities study.HGG advances · 2026Article
- Stratifying high-risk prediabetes clusters using blood-based epigenetic markers.Biomarker research · 2026Article
- Genome-wide DNA methylation patterns for indicators of liver steatosis: a longitudinal multiomic study.Clinical epigenetics · 2026Article
- Poly-epigenetic scores for cardiometabolic risk factors interact with demographic factors and health behaviors in older US Adults.Epigenetics · 2025Article
- Epigenetic mediation may explain intergenerational associations between maternal obesogenic lifestyle and children's birth weight: findings from the NorthPop prospective birth cohort.Clinical epigenetics · 2025Article
- Air pollution modulates brown adipose tissue function through epigenetic regulation by HDAC9 and KDM2B.JCI insight · 2025Article
- Novel High-Resolution Lipidomes Could Serve as New Biomarkers for Diabetic Retinopathy: A Bidirectional and Mediated Mendelian Randomization Study.Journal of cellular and molecular medicine · 2025Article
- Methylome-wide association analyses of lipids and modifying effects of behavioral factors in diverse race and ethnicity participants.Clinical epigenetics · 2025Article
- Longitudinal association between DNA methylation and type 2 diabetes: findings from the KORA F4/FF4 study.Cardiovascular diabetology · 2025Article
- Deciphering Pectin: A Comprehensive Overview of Its Origins, Processing, and Promising Utility.ACS omega · 2025Review
- DNA methylation-based predictors of metabolic traits in Scottish and Singaporean cohorts.American journal of human genetics · 2025Article
- Linking the gut microbiome to host DNA methylation by a discovery and replication epigenome-wide association study.BMC genomics · 2024Article
- Epigenome-wide mediation analysis of the relationship between psychosocial stress and cardiometabolic risk factors in the Health and Retirement Study (HRS).Clinical epigenetics · 2024Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
57 authors at 20 institutions in 9 countries.
Jun LiuDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015GD, The Netherlands. jun.liu@ndph.ox.ac.uk.ORCID http://orcid.org/0000-0001-5288-3042
Elena Carnero-MontoroDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015GD, The Netherlands.
Jenny van DongenDepartment of Biological Psychology, Amsterdam Public Health (APH) research institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, 1081BT, The Netherlands.ORCID http://orcid.org/0000-0003-2063-8741
Samantha LentDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.
Ivana NedeljkovicDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015GD, The Netherlands.ORCID http://orcid.org/0000-0002-0370-1473
Symen LigthartDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015GD, The Netherlands.
Pei-Chien TsaiDepartment of Twin Research and Genetic Epidemiology, King's College London, London, WC2R 2LS, UK.
Tiphaine C MartinDepartment of Twin Research and Genetic Epidemiology, King's College London, London, WC2R 2LS, UK.ORCID http://orcid.org/0000-0001-9990-1455
Pooja R MandaviyaDepartment of Internal Medicine, Section of Pharmacology Vascular and Metabolic Diseases, Erasmus University Medical Center, Rotterdam, 3015GD, The Netherlands.
Rick JansenDepartment of Psychiatry and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, 1081BT, The Netherlands.ORCID http://orcid.org/0000-0002-3333-6737
Marjolein J PetersDepartment of Internal Medicine, Section of Pharmacology Vascular and Metabolic Diseases, Erasmus University Medical Center, Rotterdam, 3015GD, The Netherlands.
Liesbeth DuijtsDivision of Neonatology, Department of Pediatrics, Erasmus University Medical Center, Rotterdam, 3015GD, The Netherlands.
Vincent W V JaddoeDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015GD, The Netherlands.ORCID http://orcid.org/0000-0003-2939-0041
Henning TiemeierDepartment of Child and Adolescent Psychiatry, Erasmus University Medical Center, Rotterdam, 3015GD, The Netherlands.
Janine F FelixDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015GD, The Netherlands.ORCID http://orcid.org/0000-0002-9801-5774
Gonneke WillemsenDepartment of Biological Psychology, Amsterdam Public Health (APH) research institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, 1081BT, The Netherlands.
Eco J C de GeusDepartment of Biological Psychology, Amsterdam Public Health (APH) research institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, 1081BT, The Netherlands.ORCID http://orcid.org/0000-0001-6022-2666
Audrey Y ChuThe Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, 20814, USA.
Daniel LevyThe Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, 20814, USA.
Shih-Jen HwangThe Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, 20814, USA.
Jan BresslerHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Rahul GondaliaDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27599, USA.
Elias L SalfatiDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Christian HerderGerman Center for Diabetes Research (DZD), München-Neuherberg, 85764, Germany.ORCID http://orcid.org/0000-0002-2050-093X
Bertha A HidalgoDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, 35233, USA.
Toshiko TanakaTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD, 21224, USA.
Ann Zenobia MooreTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD, 21224, USA.
Rozenn N LemaitreCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA.
Min A JhunDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0002-3575-5468
Nona SotoodehniaCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA.
Stefania BandinelliGeriatric Unit, Azienda Sanitaria di Firenze, Florence, 50137, Italy.
Luigi FerrucciTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD, 21224, USA.
Donna K ArnettSchool of Public Health, University of Kentucky, Lexington, KY, 40536, USA.
Harald GrallertGerman Center for Diabetes Research (DZD), München-Neuherberg, 85764, Germany.
Themistocles L AssimesDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0003-2349-0009
Lifang HouCenter for Population Epigenetics, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University Chicago, Evanston, IL, 60611, USA.
Andrea BaccarelliDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, 10032, USA.
Eric A WhitselDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27599, USA.ORCID http://orcid.org/0000-0003-4843-3641
Ko Willems van DijkDepartment of Human Genetics, Leiden University Medical Center, Leiden, 2333ZA, The Netherlands.ORCID http://orcid.org/0000-0002-2172-7394
Najaf AminDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015GD, The Netherlands.
André G UitterlindenDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015GD, The Netherlands.ORCID http://orcid.org/0000-0002-7276-3387
Eric J G SijbrandsDepartment of Internal Medicine, Section of Pharmacology Vascular and Metabolic Diseases, Erasmus University Medical Center, Rotterdam, 3015GD, The Netherlands.ORCID http://orcid.org/0000-0001-8857-7389
Oscar H FrancoDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015GD, The Netherlands.
Abbas DehghanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015GD, The Netherlands.
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London, WC2R 2LS, UK.
Josée DupuisDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.
Marie-France HivertDepartment of Medicine, Université de Sherbrooke, Sherbrooke, QC, J1K0A5, Canada.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences and Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
James B MeigsDepartment of Medicine, Harvard Medical School, Boston, MA, 02115, USA.
James S PankowDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA.ORCID http://orcid.org/0000-0001-7076-483X
Joyce B J van MeursCARIM School for Cardiovascular Diseases, Maastricht Centre for Systems Biology (MaCSBio), and Departments of Biochemistry and Physiology, Maastricht University, Maastricht, 6211LK, The Netherlands.
Aaron IsaacsDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015GD, The Netherlands.
Dorret I BoomsmaDepartment of Biological Psychology, Amsterdam Public Health (APH) research institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, 1081BT, The Netherlands.
Jordana T BellDepartment of Twin Research and Genetic Epidemiology, King's College London, London, WC2R 2LS, UK.
Ayşe DemirkanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015GD, The Netherlands. a.demirkan@surrey.ac.uk.
Cornelia M van DuijnDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015GD, The Netherlands. cornelia.vanduijn@ndph.ox.ac.uk.
Erasmus MC · NLAmsterdam University Medical Centers · NLKing's College London · GBNational Institute on Aging · USNational Institutes of Health · USBoston University · USStanford University · USUniversity of Michigan · USUniversity of North Carolina at Chapel Hill · USUniversity of Washington · USAmsterdam Neuroscience · NLAzienda Sanitaria di Firenze · ITBroad Institute · USChang Gung University · TWColumbia University · USDeutsches Diabetes-Zentrum e.V. · DEHarvard University · USHelmholtz Zentrum München · DELeiden University · NLLeiden University Medical Center · NL
Funding
Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1MMetabolomic Signatures for Disease Sub-classification and Target Prioritization in AMP-ADU01AG061359 · NIA · DUKE UNIVERSITY · PI KADDURAH-DAOUK, RIMA F, KASTENMULLER, GABI · 2018 to 2022
$10.0MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MRare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9MT32 Training Program in Mechanisms and Innovation in Vascular DiseaseT32HL098049 · NHLBI · STANFORD UNIVERSITY · PI Nicholas James Leeper, Philip S Tsao · 2010 to 2026
$6.3MRare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6MRare Sequence Variation and Diabetes Quantitative TraitsU01DK078616 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MEIGS, JAMES B · 2015 to 2019
$3.6MEpigenetics of Arteriosclerosis in African American Hypertensive SibshipsR01HL133221 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SMITH, JENNIFER ANN · 2016 to 2019
$2.2MEpidemiology of Precursors to Type 2 DiabetesK24DK080140 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MEIGS, JAMES B · 2007 to 2016
$1.9MEpigenomics of Cardiometabolic Diseases in Mexican AmericansK01HL130609 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HIDALGO, BERTHA · 2016 to 2019
$568kBiotechnology and Biological Sciences Research Council BB/S020845/1Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research) VIDI 016.136.361NHLBI NIH HHS K01 HL130609NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL133221NHLBI NIH HHS U01 HL120393NIA NIH HHS U01 AG061359NIDDK NIH HHS K24 DK080140NIDDK NIH HHS U01 DK078616
Abstract
Despite existing reports on differential DNA methylation in type 2 diabetes (T2D) and obesity, our understanding of its functional relevance remains limited. Here we show the effect of differential methylation in the early phases of T2D pathology by a blood-based epigenome-wide association study of 4808 non-diabetic Europeans in the discovery phase and 11,750 individuals in the replication. We identify CpGs in LETM1, RBM20, IRS2, MAN2A2 and the 1q25.3 region associated with fasting insulin, and in FCRL6, SLAMF1, APOBEC3H and the 15q26.1 region with fasting glucose. In silico cross-omics analyses highlight the role of differential methylation in the crosstalk between the adaptive immune system and glucose homeostasis. The differential methylation explains at least 16.9% of the association between obesity and insulin. Our study sheds light on the biological interactions between genetic variants driving differential methylation and gene expression in the early pathogenesis of T2D.
Indexed as
AdultAgedAged, 80 and overComputer SimulationCpG IslandsDiabetes Mellitus, Type 2DNA MethylationEpigenesis, GeneticEpigenomicsFemaleGene Expression ProfilingGene Expression RegulationGenome-Wide Association StudyGlucoseHomeostasisHumansGlucoseInsulin
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