ArticleNature communications2019
Engineering brain activity patterns by neuromodulator polytherapy for treatment of disorders.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Topographically organized dorsal raphe activity modulates forebrain sensory-motor representations and contributes to defensive behaviors.Nature communications · 2026Article
- Review
- Deep learning enhanced deciphering of brain activity maps for discovery of therapeutics for brain disorders.iScience · 2025Article
- Structural and genetic determinants of zebrafish functional brain networks.Science advances · 2025Article
- Enhanced proconvulsant sensitivity, not spontaneous rapid swimming activity, is a robust correlate ofbioRxiv : the preprint server for biology · 2025Article
- Months-long tracking of neuronal ensembles spanning multiple brain areas with Ultra-Flexible Tentacle Electrodes.Nature communications · 2024Article
- Structural and temporal dynamics analysis of neural circuit from 2002 to 2022: A bibliometric analysis.Heliyon · 2024Review
- Convergent functional change of frontoparietal network in obsessive-compulsive disorder: a voxel-based meta-analysis.Frontiers in psychiatry · 2024Review
- A Critical Review of Zebrafish Neurological Disease Models-2. Application: Functional and Neuroanatomical Phenotyping Strategies and Chemical Screens.Oxford open neuroscience · 2023Article
- Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks.Epilepsia · 2022Article
- Fish Capsules: A System for High-Throughput Screening of Combinatorial Drugs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Ketogenic Diet Alleviates Hippocampal Neurodegeneration Possibly via ASIC1a and the Mitochondria-Mediated Apoptotic Pathway in a Rat Model of Temporal Lobe Epilepsy.Neuropsychiatric disease and treatment · 2022Article
- Article
- Screening Platforms for Genetic Epilepsies-Zebrafish, iPSC-Derived Neurons, and Organoids.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Genetically Encoded Tools for Research of Cell Signaling and Metabolism under Brain Hypoxia.Antioxidants (Basel, Switzerland) · 2020Review
- Imaging epilepsy in larval zebrafish.European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2020Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Conventional drug screens and treatments often ignore the underlying complexity of brain network dysfunctions, resulting in suboptimal outcomes. Here we ask whether we can correct abnormal functional connectivity of the entire brain by identifying and combining multiple neuromodulators that perturb connectivity in complementary ways. Our approach avoids the combinatorial complexity of screening all drug combinations. We develop a high-speed platform capable of imaging more than 15000 neurons in 50ms to map the entire brain functional connectivity in large numbers of vertebrates under many conditions. Screening a panel of drugs in a zebrafish model of human Dravet syndrome, we show that even drugs with related mechanisms of action can modulate functional connectivity in significantly different ways. By clustering connectivity fingerprints, we algorithmically select small subsets of complementary drugs and rapidly identify combinations that are significantly more effective at correcting abnormal networks and reducing spontaneous seizures than monotherapies, while minimizing behavioral side effects. Even at low concentrations, our polytherapy performs superior to individual drugs even at highest tolerated concentrations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.