ArticleAntioxidants (Basel, Switzerland)2019
Synthesis of Lipophilic Esters of Tyrosol, Homovanillyl Alcohol and Hydroxytyrosol.
Article in Antioxidants (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Dimethyl-, Diethyl-, and Propylene Carbonates: An Emerging Class of Green Solvents for Organic Synthesis.Chemical record (New York, N.Y.) · 2026Review
- Metabolic engineering ofApplied and environmental microbiology · 2025Article
- Synthesis of Novel Bioactive Lipophilic Hydroxyalkyl Esters and Diesters Based on Hydroxyphenylacetic Acids.Molecules (Basel, Switzerland) · 2025Article
- Impact of pharmacokinetic enhancement strategies on the antimicrobial and antioxidant activities of hydroxytyrosol.RSC advances · 2025Article
- Sustainable Synthesis of New Antioxidants from Hydroxytyrosol by Direct Biocatalytic Esterification in Ionic Liquids.Molecules (Basel, Switzerland) · 2024Article
- Adaptive laboratory evolution of Lipomyces starkeyi for high production of lignin derivative alcohol and lipids with comparative untargeted metabolomics-based analysis.Microbial cell factories · 2024Article
- Enzymatic Modification of Pomace Olive Oil with Natural Antioxidants: Effect on Oxidative Stability.Biomolecules · 2023Article
- Hydroxytyrosol Interference with Inflammaging via Modulation of Inflammation and Autophagy.Nutrients · 2023Review
- Review
- Mitochondria-Targeted Triphenylphosphonium-Hydroxytyrosol Prevents Lipotoxicity-Induced Endothelial Injury by Enhancing Mitochondrial Function and Redox Balance via Promoting FoxO1 and Nrf2 Nuclear Translocation and Suppressing Inflammation via Inhibiting p38/NF-кB Pathway.Antioxidants (Basel, Switzerland) · 2023Article
- Natural Active Ingredients for Poly (Lactic Acid)-Based Materials: State of the Art and Perspectives.Antioxidants (Basel, Switzerland) · 2022Review
- In Vitro Anti-Proliferative and Apoptotic Effects of Hydroxytyrosyl Oleate on SH-SY5Y Human Neuroblastoma Cells.International journal of molecular sciences · 2022Article
- Green Synthesized Magnetic Nanoparticles as Effective Nanosupport for the Immobilization of Lipase: Application for the Synthesis of Lipophenols.Nanomaterials (Basel, Switzerland) · 2021Article
- New Dihydroxytyrosyl Esters from Dicarboxylic Acids: Synthesis and Evaluation of the Antioxidant Activity In Vitro (ABTS) and in Cell-Cultures (DCF Assay).Molecules (Basel, Switzerland) · 2020Article
- Natural Phenolic Compounds for Health, Food and Cosmetic Applications.Antioxidants (Basel, Switzerland) · 2020Article
- Is Green Chemistry a feasible tool for the implementation of a circular economy?Environmental science and pollution research international · 2020Article
- Effect of Sub-Minimum Inhibitory Concentrations of Tyrosol and EDTA on Quorum Sensing and Virulence ofInfection and drug resistance · 2020Article
- Health Effects of Phenolic Compounds Found in Extra-Virgin Olive Oil, By-Products, and Leaf ofNutrients · 2019Review
- Hydroxytyrosyl Oleate: Improved Extraction Procedure from Olive Oil and By-Products, and In Vitro Antioxidant and Skin Regenerative Properties.Antioxidants (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low-molecular weight phenols such as tyrosol, homovanillyl alcohol and hydroxytyrosol are valuable compounds that exhibit a high number of health-promoting effects such as antioxidant, anti-inflammatory and anticancer activity. Despite these remarkable properties, their applications such as dietary supplements and stabilizers of foods and cosmetics in non-aqueous media are limited for the hydrophilic character. With the aim to overcome this limitation, the paper describes a simple and low-cost procedure for the synthesis of lipophilic esters of tyrosol, homovanillyl alcohol and hydroxytyrosol. The reactions were carried out under mild and green chemistry conditions, at room temperature, solubilizing the phenolic compounds in dimethyl carbonate, an eco-friendly solvent, and adding a little excess of the appropriate C2-C18 acyl chloride. The final products were isolated in good yields. Finally, according to the "circular economy" strategy, the procedure was applied to hydroxytyrosol-enriched extracts obtained by
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.