Evidence map›Paper›PMID 31197038›Full record

ReviewThe Journal of biological chemistry2019

Trouble is coming: Signaling pathways that regulate general stress responses in bacteria.

Susan Gottesman

Open access · hybridAbstract readReview
In one paragraph

Review in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers.

0numbers the graph read from it
0cells of the map it votes in
158citing papers in PubMed
22.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

158 citing papers in PubMed, 268 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Transcriptional landscape of metal-resistantJournal of bacteriology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Simple biological controllers drive the evolution of soft modes.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Regulation of indigoidine production inJournal of bacteriology · 2026
    Article
  18. Article
  19. Article
  20. ModelingbioRxiv : the preprint server for biology · 2025
    Article

98 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Susan GottesmanLaboratory of Molecular Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892 gottesms@mail.nih.gov.
National Institutes of Health · US

Funding

Proteolysis and Regulation of Bacterial Cell Growth ControlZIABC011203 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GOTTESMAN, SUSAN · 2009 to 2025
$11.0M
6 · The paper itself

Abstract

Bacteria can rapidly and reversibly respond to changing environments via complex transcriptional and post-transcriptional regulatory mechanisms. Many of these adaptations are specific, with the regulatory output tailored to the inducing signal (for instance, repairing damage to cell components or improving acquisition and use of growth-limiting nutrients). However, the general stress response, activated in bacterial cells entering stationary phase or subjected to nutrient depletion or cellular damage, is unique in that its common, broad output is induced in response to many different signals. In many different bacteria, the key regulator for the general stress response is a specialized sigma factor, the promoter specificity subunit of RNA polymerase. The availability or activity of the sigma factor is regulated by complex regulatory circuits, the majority of which are post-transcriptional. In

Indexed as

Signal TransductionStress, PhysiologicalBacteriaBacterial ProteinsEscherichia coliHost Factor 1 ProteinProtein BiosynthesisRNA, Small UntranslatedSigma FactorBacterial ProteinsHost Factor 1 ProteinRNA, Small UntranslatedSigma Factorsigma factor KatF protein, Bacteriaanti-adaptorClpXPEscherichia coli (E. coli)general stress responseHfq proteinprokaryotic signal-transductionproteolysisRNARNA polymeraseRpoS

Identifiers

PMID31197038
PMCPMC6682744
OpenAlexW2951896693

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.