ArticleScience (New York, N.Y.)2019
Long-duration hippocampal sharp wave ripples improve memory.
Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 267 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
267 citing papers in PubMed.
- Sleep EEG oscillations and synaptic plasticity in memory consolidation across NREM and REM sleep.Dialogues in clinical neuroscience · 2027Review
- Article
- A wireless modular platform for neuro-behavioral recording and closed-loop manipulation in small animals.Nature methods · 2026Article
- Article
- Integrating neural decoding, memristive materials, and adaptive control frameworks for next-generation hippocampal memory prosthetics.iScience · 2026Review
- Article
- Article
- Offline generative network reconfiguration guides insight-like accelerated learning by assimilation into schema in rats.Nature communications · 2026Article
- Goal-directed hippocampal theta sweeps during memory-guided navigation.Nature neuroscience · 2026Article
- Neurobiological mechanisms of 40-Hz stimulation in Alzheimer's disease: evidence, heterogeneity, and constraints.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Drift-diffusion dynamics of hippocampal replay.PLoS computational biology · 2026Article
- The default mode network exhibits circuit-specific selective vulnerability despite widespread amyloid burden in an animal model of Alzheimer's disease.Nature communications · 2026Article
- The choice-wide behavioral association study: data-driven identification of interpretable behavioral components.Nature communications · 2026Article
- High-frequency visual stimulation can increase medial temporal lobe ripple oscillation density.Communications medicine · 2026Article
- Exposure to broadband noise during non-REM sleep impairs hippocampal sharp-wave ripples and memory consolidation.Current biology : CB · 2026Article
- Anti-NMDAR encephalitis impairs intrinsic hippocampal dynamics through neuronal hypercoupling, hub dominance, and aberrant ensembles.Molecular psychiatry · 2026Article
- Human hippocampal ripples tune cortical responses based on predicted uncertainty.Nature neuroscience · 2026Article
- Review
- Postoperative Impairment of GluA2 Ttrafficking in CA3 Induces Memory Consolidation Deficits in Aged Mice by Disrupting SPW-R in CA1.Journal of molecular neuroscience : MN · 2026Article
- Arousal state modulates human hippocampal ripples.bioRxiv : the preprint server for biology · 2026Article
207 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Hippocampal sharp wave ripples (SPW-Rs) have been hypothesized as a mechanism for memory consolidation and action planning. The duration of ripples shows a skewed distribution with a minority of long-duration events. We discovered that long-duration ripples are increased in situations demanding memory in rats. Prolongation of spontaneously occurring ripples by optogenetic stimulation, but not randomly induced ripples, increased memory during maze learning. The neuronal content of randomly induced ripples was similar to short-duration spontaneous ripples and contained little spatial information. The spike content of the optogenetically prolonged ripples was biased by the ongoing, naturally initiated neuronal sequences. Prolonged ripples recruited new neurons that represented either arm of the maze. Long-duration hippocampal SPW-Rs replaying large parts of planned routes are critical for memory.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.