ArticleThe Journal of experimental medicine2019
Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons.
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Article in The Journal of experimental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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58citing papers in PubMed
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58 citing papers in PubMed, 101 citations in OpenAlex.
- TRPM2 is a direct pain transducer.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Protective and Pathogenic Antibodies to Citrullinated Antigens.Immunological reviews · 2026Review
- Inhibition of Janus kinase/signal transducer and activator of transcription reduces nociceptive sensitization in a murine model of complex regional pain syndrome.Pain reports · 2026Article
- CRP Is a Key Indicator of Rheumatoid Arthritis-Associated Vascular Injury and Neurodegeneration.International journal of molecular sciences · 2026Review
- Persistent interferon signaling causes sensory neuron plasticity and pain before and during arthritis.Nature neuroscience · 2026Article
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- Emerging concepts in osteoarthritis and musculoskeletal diseases: Insights from the University of Debrecen Musculoskeletal Symposium 2025.Osteoarthritis and cartilage open · 2026Article
- Pathogenic Drivers of Difficult-to-Treat Rheumatoid Arthritis: Synovium and Beyond.International journal of molecular sciences · 2026Review
- Nociplastic pain: the prominent role of non-neuronal cells in central and peripheral sensitization.Frontiers in immunology · 2026Review
- NKG2D receptor ligands are cell surface biomarkers for injured murine and human nociceptive sensory neurons.Journal of neuroinflammation · 2025Article
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- Moon Jellyfish Mucin and Collagen Attenuate Catabolic Activity in Chondrocytes but Show Limited Efficacy in an Osteoarthritis Rat Model.International journal of molecular sciences · 2025Article
- Fc gamma receptor IIa signaling from spinal cord astrocytes promotes neuropathic pain in rats.The journal of pain · 2025Article
- The hot spots and trends of Fc gamma receptor: A bibliometric analysis from 2004 to 2024.Medicine · 2025Article
- Reducing IgG accumulation via neonatal Fc receptor (FcRn) blockade relieves neuropathic pain.Brain, behavior, and immunity · 2025Article
- Pain kept under wraps of myelin sheath.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Autoantibodies cause nociceptive sensitization in a mouse model of degenerative osteoarthritis.Pain · 2024Article
- Transcriptome analysis of rheumatoid arthritis uncovers genes linked to inflammation-induced pain.Scientific reports · 2024Article
- The influence of sex on neuroimmune communication, pain, and physiology.Biology of sex differences · 2024Review
- B cells drive neuropathic pain-related behaviors in mice through IgG-Fc gamma receptor signaling.Science translational medicine · 2024Article
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Authors and funding
31 authors at 8 institutions in 6 countries.
Alex Bersellini Farinotti *Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Gustaf Wigerblad *Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-1798-4347
Diana Nascimento *Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-3765-4801
Duygu B BasDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Carlos Morado UrbinaDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Kutty Selva NandakumarSection for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-7790-8197
Katalin SandorDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-3228-6907
Bingze XuSection for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-5341-1722
Sally AbdelmoatyDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Matthew A HuntDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Kristina Ängeby MöllerDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Azar BaharpoorDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Jon SinclairDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Kent JardemarkDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Johanna T LannerDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-1222-9473
Ia KhmaladzeSection for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Lars E BormDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-1764-6057
Lu ZhangDepartment of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-8871-0079
Fredrik WermelingDepartment of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0001-9633-677X
Mark S CraggCentre for Cancer Immunology, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK.ORCID 0000-0003-2077-089X
Johan LengqvistDepartment of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Anne-Julie Chabot-DoréAlan Edwards Centre for Research on Pain, McGill University, Montréal, Quebec, Canada.
Luda DiatchenkoAlan Edwards Centre for Research on Pain, McGill University, Montréal, Quebec, Canada.
Inna BelferOffice of Research on Women's Health, National Institutes of Health, Bethesda, MD.
Mattias CollinDivision of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden.ORCID 0000-0002-6166-7410
Kim KultimaDepartment of Medical Science, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-0680-1410
Birgitta HeymanDepartment of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.ORCID 0000-0003-0869-0483
Juan Miguel Jimenez-AndradeDepartment of Unidad Academica Multidisciplinaria Reynosa Aztlan, Universidad Autonoma de Tamaulipas, Reynosa, Tamaulipas, Mexico.
Simone CodeluppiDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Rikard Holmdahl *Section for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden rikard.holmdahl@ki.se.ORCID 0000-0002-4969-2576
Camilla I Svensson *Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden camilla.svensson@ki.se.ORCID 0000-0001-7980-4631
Karolinska Institutet · SEUppsala University · SEKarolinska University Hospital · SEMcGill University · CAAutonomous University of Tamaulipas · MXLund University · SENational Institutes of Health · USSouthampton General Hospital · GB
Funding
Rheumatic Diseases Research Training GrantT32AR064194 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GARY S FIRESTEIN, Monica Guma · 2013 to 2026
$3.8MCancer Research UK 24721NIAMS NIH HHS T32 AR064194
Abstract
Rheumatoid arthritis-associated joint pain is frequently observed independent of disease activity, suggesting unidentified pain mechanisms. We demonstrate that antibodies binding to cartilage, specific for collagen type II (CII) or cartilage oligomeric matrix protein (COMP), elicit mechanical hypersensitivity in mice, uncoupled from visual, histological and molecular indications of inflammation. Cartilage antibody-induced pain-like behavior does not depend on complement activation or joint inflammation, but instead on tissue antigen recognition and local immune complex (IC) formation. smFISH and IHC suggest that neuronal
Indexed as
AnimalsAntibodies, MonoclonalAntigen-Antibody ComplexArthralgiaArthritis, RheumatoidAutoantibodiesBehavior, AnimalCartilageCartilage Oligomeric Matrix ProteinCollagen Type IIDisease Models, AnimalFemaleMaleMiceMice, Inbred BALB CMice, Inbred C57BLAntibodies, MonoclonalAntigen-Antibody ComplexAutoantibodiesCartilage Oligomeric Matrix ProteinCollagen Type IIComp protein, mouseReceptors, IgG
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