Evidence map›Paper›PMID 31196969›Full record

ArticleMolecular & cellular proteomics : MCP2019

Regulated Phosphosignaling Associated with Breast Cancer Subtypes and Druggability.

Kuan-Lin Huang, Yige Wu, Tina Primeau, Yi-Ting Wang, Yuqian Gao, Joshua F McMichael, Adam D Scott, Song Cao, Michael C Wendl, Kimberly J Johnson and 16 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular & cellular proteomics : MCP, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 8 institutions in 1 country.

Kuan-Lin Huang‡Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029; §Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029; ¶Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029. Electronic address: kuan-lin.huang@mssm.edu.
Yige Wu**Department of Medicine, Washington University in St. Louis, MO 63108; ‡‡McDonnell Genome Institute, Washington University in St. Louis, MO 63108.
Tina Primeau‡‡McDonnell Genome Institute, Washington University in St. Louis, MO 63108.
Yi-Ting Wang§§§Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352.
Yuqian Gao§§§Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352.
Joshua F McMichael**Department of Medicine, Washington University in St. Louis, MO 63108.
Adam D Scott**Department of Medicine, Washington University in St. Louis, MO 63108; ‡‡McDonnell Genome Institute, Washington University in St. Louis, MO 63108.
Song Cao**Department of Medicine, Washington University in St. Louis, MO 63108; ‡‡McDonnell Genome Institute, Washington University in St. Louis, MO 63108.
Michael C Wendl‡‡McDonnell Genome Institute, Washington University in St. Louis, MO 63108; §§Department of Genetics, Washington University in St. Louis, MO 63108; ¶¶Department of Mathematics, Washington University in St. Louis, MO 63108. Electronic address: lding@genome.wustl.edu.
Kimberly J Johnson‖‖Siteman Cancer Center, Washington University in St. Louis, MO 63108; ‡‡‡Brown School of Social Work, Washington University in St. Louis, MO 63108.
Kelly Ruggles¶¶¶Center for Health Informatics and Bioinformatics, New York University School of Medicine, New York, NY 10016.
Jason Held**Department of Medicine, Washington University in St. Louis, MO 63108; ‖‖Siteman Cancer Center, Washington University in St. Louis, MO 63108.
Samuel H Payne§§§Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352.
Sherri Davies**Department of Medicine, Washington University in St. Louis, MO 63108; ‖‖Siteman Cancer Center, Washington University in St. Louis, MO 63108.
Arvin Dar‖Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Christopher R Kinsinger‖‖‖National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Mehdi Mesri‖‖‖National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Henry Rodriguez‖‖‖National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Matthew J Ellis‡‡‡‡Dan L. Duncan Cancer Center & Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030.
R Reid Townsend**Department of Medicine, Washington University in St. Louis, MO 63108; ‖‖Siteman Cancer Center, Washington University in St. Louis, MO 63108.
Feng Chen**Department of Medicine, Washington University in St. Louis, MO 63108; ‖‖Siteman Cancer Center, Washington University in St. Louis, MO 63108.
David Fenyö¶¶Department of Mathematics, Washington University in St. Louis, MO 63108.
Shunqiang Li**Department of Medicine, Washington University in St. Louis, MO 63108; ‖‖Siteman Cancer Center, Washington University in St. Louis, MO 63108.
Tao Liu‡‡McDonnell Genome Institute, Washington University in St. Louis, MO 63108.
Steven A Carr§§§§The Broad Institute of MIT and Harvard, Cambridge, MA 02142.
Li Ding**Department of Medicine, Washington University in St. Louis, MO 63108; §§Department of Genetics, Washington University in St. Louis, MO 63108; ‖‖Siteman Cancer Center, Washington University in St. Louis, MO 63108.
Washington University in St. Louis · USJames S. McDonnell Foundation · USNational Institutes of Health · USPacific Northwest National Laboratory · USIcahn School of Medicine at Mount Sinai · USBaylor College of Medicine · USBroad Institute · USNew York University · US

Funding

Cancer Proteome Center at Washington Univ, Univ of North Carolina & Boise StateU24CA160035 · NCI · WASHINGTON UNIVERSITY · PI CHEN, XIAN, ELLIS, MATTHEW J · 2011 to 2016
$11.8M
PNNL Proteome Characterization CenterU24CA210955 · NCI · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI LIU, TAO, SMITH, RICHARD D · 2016 to 2020
$5.3M
Proteogenomic Data Analysis for Cancer Systems Biology and Clinical TranslationU24CA210972 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DING, LI, FENYO, DAVID · 2016 to 2020
$3.3M
A Turnkey System for High-throughput Variant Discovery and InterpretationU01HG006517 · NHGRI · WASHINGTON UNIVERSITY · PI DING, LI · 2012 to 2015
$3.0M
Deep Discovery and Clinical Interpretation of Germline and Somatic Cancer DriversU24CA211006 · NCI · WASHINGTON UNIVERSITY · PI DING, LI, GOVINDAN, RAMASWAMY · 2016 to 2020
$1.8M
NCI NIH HHS U24 CA160035NCI NIH HHS U24 CA210955NCI NIH HHS U24 CA210972NCI NIH HHS U24 CA211006NHGRI NIH HHS U01 HG006517
6 · The paper itself

Abstract

Aberrant phospho-signaling is a hallmark of cancer. We investigated kinase-substrate regulation of 33,239 phosphorylation sites (phosphosites) in 77 breast tumors and 24 breast cancer xenografts. Our search discovered 2134 quantitatively correlated kinase-phosphosite pairs, enriching for and extending experimental or binding-motif predictions. Among the 91 kinases with

Indexed as

Breast NeoplasmsFemaleHumansPhosphorylationProtein KinasesSignal TransductionProtein KinasesBioinformaticsBreast cancerDrug targets*Kinases*Mass SpectrometryPhosphorylationSignaling Molecules*

Identifiers

PMID31196969
PMCPMC6682998
OpenAlexW2950171351

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.