Evidence map›Paper›PMID 31196959›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

How the avidity of polymerase binding to the -35/-10 promoter sites affects gene expression.

Tal Einav, Rob Phillips

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 49 citations in OpenAlex.

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  15. Engineering ofInternational journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Tal EinavDepartment of Physics, California Institute of Technology, Pasadena, CA 91125; phillips@pboc.caltech.edu tal.einav@alumni.caltech.edu.ORCID 0000-0003-0777-1193
Rob PhillipsDepartment of Physics, California Institute of Technology, Pasadena, CA 91125; phillips@pboc.caltech.edu tal.einav@alumni.caltech.edu.ORCID 0000-0003-3082-2809
California Institute of Technology · US

Funding

The Principles of Regulatory, Conformational and Evolutionary AdaptationR35GM118043 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ROB PHILLIPS · 2016 to 2026
$7.9M
NIGMS NIH HHS R35 GM118043
6 · The paper itself

Abstract

Although the key promoter elements necessary to drive transcription in

Indexed as

Promoter Regions, GeneticBinding SitesDNADNA-Directed RNA PolymerasesEscherichia coliGene ExpressionGene Expression RegulationModels, GeneticTranscription, GeneticDNADNA-Directed RNA Polymerasesaviditystatistical mechanicstranscription regulation

Identifiers

PMID31196959
PMCPMC6613100
OpenAlexW2931132537

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.