ArticleProceedings of the National Academy of Sciences of the United States of America2019
Reversible silencing of endogenous receptors in intact brain tissue using 2-photon pharmacology.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- Photopharmacological Cholinergic Modulation of Cortical Activity in Human Brain Slices.Brain sciences · 2026Article
- OptoHMolecular brain · 2026Article
- Targeted Covalent Photoswitch for Two-Photon Control of Endogenous Receptors.Journal of the American Chemical Society · 2026Article
- Noninvasive cardiac modulation via triplet-sensitized photoswitching in the phototherapeutic window.Nature communications · 2025Article
- Photoswitchable positive allosteric modulators of metabotropic glutamate receptor 4 to improve selectivity.iScience · 2024Article
- Reversible Photocontrol of Dopaminergic Transmission in Wild-Type Animals.International journal of molecular sciences · 2022Article
- Advances in nonlinear optical microscopy techniques for in vivo and in vitro neuroimaging.Biophysical reviews · 2021Review
- Control of Brain State Transitions with a Photoswitchable Muscarinic Agonist.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Two-photon absorption and two-photon-induced isomerization of azobenzene compounds.RSC advances · 2020Review
- Improved tools to study astrocytes.Nature reviews. Neuroscience · 2020Review
- Photoswitching endogenous glutamate receptors in neural ensembles and single synapses in vivo.Brain stimulationArticle
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
Abstract
The physiological activity of proteins is often studied with loss-of-function genetic approaches, but the corresponding phenotypes develop slowly and can be confounding. Photopharmacology allows direct, fast, and reversible control of endogenous protein activity, with spatiotemporal resolution set by the illumination method. Here, we combine a photoswitchable allosteric modulator (alloswitch) and 2-photon excitation using pulsed near-infrared lasers to reversibly silence metabotropic glutamate 5 (mGlu
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.