Evidence map›Paper›PMID 31196899›Full record

ArticleBMJ open2019

Chewing gum to treat postoperative nausea and emesis in female patients (CHEWY): rationale and design for a multicentre randomised trial.

Jai Darvall, Britta Sylvia von Ungern-Sternberg, Sabine Braat, David Story, Andrew Davidson, Megan Allen, An Tran-Duy, Dana Middleton, Kate Leslie

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Chewing gum prophylaxis for postoperative nausea and vomiting in the intensive care unit: a pilot randomised controlled trial.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2020
    Article
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Jai DarvallDepartment of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Victoria, Australia.ORCID 0000-0003-0579-8931
Britta Sylvia von Ungern-SternbergDepartment of Anaesthesia and Pain Management, Perth Children's Hospital, Perth, Western Australia, Australia.
Sabine BraatCentre for Epidemiology and Biostatistics and Melbourne Clinical and Translational Science Platform, University of Melbourne School of Population and Global Health, Melbourne, Victoria, Australia.
David StoryCentre for Integrated Critical Care, University of Melbourne, Melbourne, Victoria, Australia.
Andrew DavidsonDepartment of Anaesthesia, Royal Children's Hospital Melbourne, Melbourne, Victoria, Australia.
Megan AllenDepartment of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
An Tran-DuyCentre for Health Policy, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Dana MiddletonDepartment of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Kate LeslieDepartment of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
The Royal Melbourne Hospital · AUThe University of Melbourne · AURoyal Children's Hospital · AUThe University of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPostoperative nausea, retching and vomiting (PONV) remains one of the most common side effects of general anaesthesia, contributing significantly to patient dissatisfaction, cost and complications. Chewing gum has potential as a novel, drug-free alternative treatment. We aim to conduct a large, definitive randomised controlled trial of the efficacy and safety of peppermint-flavoured chewing gum to treat PONV in the postanaesthesia care unit (PACU). If chewing gum is shown to be as effective as ondansetron, this trial has the potential to significantly improve outcomes for tens of millions of surgical patients around the world each year. METHODS AND ANALYSIS: This is a prospective, multicentre, randomised controlled non-inferiority trial. 272 female patients aged ≥12 years having volatile anaesthetic-based general anaesthesia for breast or laparoscopic surgery will be randomised. Patients experiencing nausea, retching or vomiting in PACU will be randomised to 15 min of chewing gum or 4 mg intravenous ondansetron. The primary outcome (complete response) is cessation of PONV within 2 hours of administration, with no recurrence nor rescue medication requirement for 2 hours after administration. ETHICS AND DISSEMINATION: The Chewy Trial has been approved by the Human Research Ethics Committees at all sites. Dissemination will be via international and national anaesthesia conferences, and publication in the peer-reviewed literature. TRIAL REGISTRATION NUMBER: ACTRN12618000429257; Pre-results.

Indexed as

Chewing GumAdolescentAdultAnesthesia, GeneralAntiemeticsDouble-Blind MethodEquivalence Trials as TopicFeasibility StudiesFemaleHumansInjections, IntravenousMiddle AgedMulticenter Studies as TopicOndansetronPostoperative Nausea and VomitingProspective StudiesAntiemeticsChewing GumOndansetronchewing gumondansetronperioperative complications/outcomespostanaesthesia nursingpostoperative nausea and vomitingrecovery

Identifiers

PMID31196899
PMCPMC6575709
OpenAlexW2953254732

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.