ArticleAJNR. American journal of neuroradiology2019
Subject-Specific Studies of CSF Bulk Flow Patterns in the Spinal Canal: Implications for the Dispersion of Solute Particles in Intrathecal Drug Delivery.
Article in AJNR. American journal of neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 28 citations in OpenAlex.
- How brain pulsations drive solute transport in the cranial subarachnoid space: insights from a toy model.Journal of the Royal Society, Interface · 2026Article
- Mechanistic multiphysics modeling reveals how blood pulsation drives CSF flow, pressure, and brain deformation under physiological and injection conditions.Fluids and barriers of the CNS · 2026Article
- Patient-specific CFD modeling of CSF flow in Chiari I malformation: denticulate-ligament-induced compartmentalization explains flow patterns.Fluids and barriers of the CNS · 2026Article
- A 3D non-human primate digital model for pharmacokinetic prediction of intra-cerebrospinal fluid drug neuraxial dispersion.Fluids and barriers of the CNS · 2025Article
- Mixed-dimensional fluid-structure interaction simulations reveal key mechanisms of cerebrospinal fluid dynamics in the spinal canal.Fluids and barriers of the CNS · 2025Article
- On reduced-order modeling of drug dispersion in the spinal canal.Fluids and barriers of the CNS · 2025Article
- Arterial pulsations and transmantle pressure synergetically drive glymphatic flow.Scientific reports · 2025Article
- An In Vitro Platform for Pharmacokinetic Quantification and Optimization of Cerebrospinal Fluid Filtration and Drug Circulation.Journal of medical devices · 2025Article
- Numerical study of the effects of minor structures and mean velocity fields in the cerebrospinal fluid flow.Fluids and barriers of the CNS · 2024Article
- Visualization of Cerebrospinal Fluid Outflow and Egress along the Nerve Roots of the Lumbar Spine.Bioengineering (Basel, Switzerland) · 2024Article
- Effects of buoyancy on the dispersion of drugs released intrathecally in the spinal canal.Journal of fluid mechanics · 2024Article
- Neurofluids and the glymphatic system: anatomy, physiology, and imaging.The British journal of radiology · 2023Review
- Stationary flow driven by non-sinusoidal time-periodic pressure gradients in wavy-walled channels.Applied mathematical modelling · 2023Article
- Article
- Oscillating viscous flow past a streamwise linear array of circular cylinders.Journal of fluid mechanics · 2023Article
- A mechanistic pharmacokinetic model for intrathecal administration of antisense oligonucleotides.Frontiers in physiology · 2023Article
- Cerebrospinal Fluid Flow.Annual review of fluid mechanics · 2023Article
- Buoyancy-modulated Lagrangian drift in wavy-walled vertical channels as a model problem to understand drug dispersion in the spinal canal.Journal of fluid mechanics · 2022Article
- Effect of Normal Breathing on the Movement of CSF in the Spinal Subarachnoid Space.AJNR. American journal of neuroradiology · 2022Article
- A one-dimensional model for the pulsating flow of cerebrospinal fluid in the spinal canal.Journal of fluid mechanics · 2022Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeRecent flow dynamics studies have shown that the eccentricity of the spinal cord affects the magnitude and characteristics of the slow bulk motion of CSF in the spinal subarachnoid space, which is an important variable in solute transport along the spinal canal. The goal of this study was to investigate how anatomic differences among subjects affect this bulk flow. MATERIALS AND
methodsT2-weighted spinal images were obtained in 4 subjects and repeated in 1 subject after repositioning. CSF velocity was calculated from phase-contrast MR images for 7 equally spaced levels along the length of the spine. This information was input into a 2-time-scale asymptotic analysis of the Navier-Stokes and concentration equations to calculate the short- and long-term CSF flow in the spinal subarachnoid space. Bulk flow streamlines were shown for each subject and position and inspected for differences in patterns.
resultsThe 4 subjects had variable degrees of lordosis and kyphosis. Repositioning in 1 subject changed the degree of cervical lordosis and thoracic kyphosis. The streamlines of bulk flow show the existence of distinct regions where the fluid particles flow in circular patterns. The location and interconnectivity of these recirculating regions varied among individuals and different positions.
conclusionsLordosis, kyphosis, and spinal cord eccentricity in the healthy human spine result in subject-specific patterns of bulk flow recirculating regions. The extent of the interconnectivity of the streamlines among these recirculating regions is fundamental in determining the long-term transport of solute particles along the spinal canal.
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