Evidence map›Paper›PMID 31196835›Full record

Trial reportBrain stimulation

Effects of 6-month at-home transcranial direct current stimulation on cognition and cerebral glucose metabolism in Alzheimer's disease.

Jooyeon Jamie Im, Hyeonseok Jeong, Marom Bikson, Adam J Woods, Gozde Unal, Jin Kyoung Oh, Seunghee Na, Jong-Sik Park, Helena Knotkova, In-Uk Song and 1 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 15 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 15 syntheses or guidelines pooled it, 168 citations in OpenAlex.

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  8. Transcranial direct current stimulation for global cognition in Alzheimer's disease: a systemic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
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  14. The role of noninvasive brain stimulation for behavioral and psychological symptoms of dementia: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
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37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Jooyeon Jamie ImDepartment of Radiology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Hyeonseok JeongDepartment of Radiology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Marom BiksonDepartment of Biomedical Engineering, The City College of New York, New York, NY, USA.
Adam J WoodsCenter for Cognitive Aging and Memory, McKnight Brain Institute, Department of Clinical and Health Psychology, University of Florida, FL, USA.
Gozde UnalDepartment of Biomedical Engineering, The City College of New York, New York, NY, USA.
Jin Kyoung OhDepartment of Radiology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Seunghee NaDepartment of Neurology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Jong-Sik ParkDepartment of Neurology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Helena KnotkovaMJHS Institute for Innovation in Palliative Care, New York, NY, USA; Department of Family and Social Medicine, Albert Einstein College of Medicine, The Bronx, NY, USA.
In-Uk SongDepartment of Neurology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea. Electronic address: siuy@catholic.ac.kr.
Yong-An ChungDepartment of Radiology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea. Electronic address: yongan@catholic.ac.kr.
The Catholic University of Korea Incheon St. Mary's Hospital · KRCity College of New York · USAlbert Einstein College of Medicine · USUniversity of Florida · US

Funding

Augmenting Cognitive Training in Older Adults - The ACT GrantR01AG054077 · NIA · UNIVERSITY OF FLORIDA · PI COHEN, RONALD A, MARSISKE, MICHAEL · 2016 to 2020
$6.9M
Together: Transforming and Translating Discovery to Improve HealthKL2TR001429 · NCATS · UNIVERSITY OF FLORIDA · PI GUIRGIS, FAHEEM W, LEEUWENBURGH, CHRISTIAAN · 2015 to 2023
$5.5M
A tool-box to control and enhance tDCS spatial precisionR01MH111896 · NIMH · CITY COLLEGE OF NEW YORK · PI BIKSON, MAROM · 2016 to 2019
$2.2M
The coupled vascular hypothesis for transcranial direct current stimulation (tDCS)R01NS101362 · NINDS · CITY COLLEGE OF NEW YORK · PI BIKSON, MAROM · 2017 to 2021
$1.7M
Neuromodulation of Cognition in Older AdultsK01AG050707 · NIA · UNIVERSITY OF FLORIDA · PI WOODS, ADAM J. · 2016 to 2020
$613k
NCATS NIH HHS KL2 TR001429NIA NIH HHS K01 AG050707NIA NIH HHS R01 AG054077NIMH NIH HHS R01 MH111896NINDS NIH HHS R01 NS101362
6 · The paper itself

Abstract

backgroundAlthough single or multiple sessions of transcranial direct current stimulation (tDCS) on the prefrontal cortex over a few weeks improved cognition in patients with Alzheimer's disease (AD), effects of repeated tDCS over longer period and underlying neural correlates remain to be elucidated.

objectiveThis study investigated changes in cognitive performances and regional cerebral metabolic rate for glucose (rCMRglc) after administration of prefrontal tDCS over 6 months in early AD patients.

methodsPatients with early AD were randomized to receive either active (n = 11) or sham tDCS (n = 7) over the dorsolateral prefrontal cortex (DLPFC) at home every day for 6 months (anode F3/cathode F4, 2 mA for 30 min). All patients underwent neuropsychological tests and brain

resultsCompared to sham tDCS, active tDCS improved global cognition measured with Mini-Mental State Examination (p for interaction = 0.02) and language function assessed by Boston Naming Test (p for interaction = 0.04), but not delayed recall performance. In addition, active tDCS prevented decreases in executive function at a marginal level (p for interaction < 0.10). rCMRglc in the left middle/inferior temporal gyrus was preserved in the active group, but decreased in the sham group (p for interaction < 0.001).

conclusionsDaily tDCS over the DLPFC for 6 months may improve or stabilize cognition and rCMRglc in AD patients, suggesting the therapeutic potential of repeated at-home tDCS.

Indexed as

Home Care ServicesAgedAged, 80 and overAlzheimer DiseaseCognitionDouble-Blind MethodExecutive FunctionFemaleFollow-Up StudiesGlucoseHumansMaleMiddle AgedNeuropsychological TestsPositron-Emission TomographyPrefrontal CortexGlucoseAlzheimer's diseaseCognitionPositron emission tomographyRegional cerebral metabolic rate for glucoseTranscranial direct current stimulation

Identifiers

PMID31196835
PMCPMC6703942
OpenAlexW2948590640

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.