ArticleUltrasound in medicine & biology2019
In Vitro Superharmonic Contrast Imaging Using a Hybrid Dual-Frequency Probe.
Article in Ultrasound in medicine & biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Current trends in the characterization and monitoring of vascular response to cancer therapy.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Review
- Superharmonic and Microultrasound Imaging With Plane Wave Beamforming Techniques.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023Article
- A Handheld Imaging Probe for Acoustic Angiography With an Ultrawideband Capacitive Micromachined Ultrasonic Transducer (CMUT) Array.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Acoustic Molecular Imaging Beyond the Diffraction Limit In Vivo.IEEE open journal of ultrasonics, ferroelectrics, and frequency control · 2022Article
- Acoustic Angiography: Superharmonic Contrast-Enhanced Ultrasound Imaging for Noninvasive Visualization of Microvasculature.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Implementation of a Novel 288-Element Dual-Frequency Array for Acoustic Angiography: In Vitro and In Vivo Characterization.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Characterization of an Array-Based Dual-Frequency Transducer for Superharmonic Contrast Imaging.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles.Ultrasonics sonochemistry · 2021Article
- An Improved CMUT Structure Enabling Release and Collapse of the Plate in the Same Tx/Rx Cycle for Dual-Frequency Acoustic Angiography.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2020Article
- Visualization of Microvascular Angiogenesis Using Dual-Frequency Contrast-Enhanced Acoustic Angiography: A Review.Ultrasound in medicine & biology · 2020Review
- From Anatomy to Functional and Molecular Biomarker Imaging and Therapy: Ultrasound Is Safe, Ultrafast, Portable, and Inexpensive.Investigative radiology · 2020Review
- Perspectives on high resolution microvascular imaging with contrast ultrasound.Applied physics letters · 2020Article
- Superharmonic Ultrasound for Motion-Independent Localization Microscopy: Applications to Microvascular Imaging From Low to High Flow Rates.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2020Article
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Authors and funding
7 authors.
Funding
Abstract
Superharmonic imaging is an ultrasound contrast imaging technique that differentiates microbubble echoes from tissue through detection of higher-order bubble harmonics in a broad frequency range well above the excitation frequency. Application of superharmonic imaging in three dimensions allows specific visualization of the tissue microvasculature with high resolution and contrast, a technique referred to as acoustic angiography. Because of the need to transmit and receive across a bandwidth that spans up to the fifth harmonic of the fundamental and higher, this imaging approach requires imaging probes comprising dedicated transducers for transmit and receive. In this work, we report on a new dual-frequency probe including two 1.7-MHz rectangular transducers positioned one on each side of a 20-MHz 256-element array. Finite element modeling-based design, fabrication processes and assembly of the transducer are described, as is integration with a high-frequency ultrasound imaging platform. Dual-frequency single-plane-wave imaging was performed with a microbubble contrast agent in flow phantoms and compared with conventional high-frequency B-mode imaging, and resolution and contrast-to-tissue ratio were quantified. This work represents an intermediate but informative step toward the development of dual-frequency imaging probes based on array technology, specifically designed for clinical applications of acoustic angiography.
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