ArticleProgress in brain research2019
Dispositional negativity, cognition, and anxiety disorders: An integrative translational neuroscience framework.
Article in Progress in brain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The hierarchical taxonomy of psychopathology and the search for neurobiological substrates of mental illness: A systematic review and roadmap for future research.Journal of psychopathology and clinical science · 2024Pooled it
- A proof of concept study on digital interventions for reducing socio-evaluative stress and anxiety in youth.Scientific reports · 2025Trial
- Trial
- Noninvasive Suppression of Responses to Threat Using Focused Ultrasonic Waves.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Reduced Threat-Related Neural Efficiency: A Possible Biomarker for Pediatric Anxiety Disorders.The American journal of psychiatry · 2026Article
- Targeting neurobehavioral substrates of effortful control to reduce childhood anxiety: The Camp Kidpower study protocol.Research square · 2025Article
- Affective dynamics and emotional reactivity in social anxiety disorder.Psychological medicine · 2025Article
- Heightened subcortical reactivity to uncertain-threat is associated with future internalizing symptoms, conditional on stress exposure.bioRxiv : the preprint server for biology · 2025Article
- Hippocampal, thalamic, and amygdala subfield morphology in major depressive disorder: an ultra-high resolution MRI study at 7-Tesla.European archives of psychiatry and clinical neuroscience · 2025Article
- A Shared Threat-Anticipation Circuit Is Dynamically Engaged at Different Moments by Certain and Uncertain Threat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neuroticism modulates functional connectivity of the midcingulate cortex during emotional conflict.Scientific reports · 2025Article
- A shared threat-anticipation circuit is dynamically engaged at different moments by certain and uncertain threat.bioRxiv : the preprint server for biology · 2025Article
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- Article
- Adolescent social anxiety is associated with diminished discrimination of anticipated threat and safety in the bed nucleus of the stria terminalis.Journal of psychopathology and clinical science · 2025Article
- An Honest Reckoning With the Amygdala and Mental Illness.The American journal of psychiatry · 2024Review
- Neuroticism Is Prospectively Associated With 30-Month Changes in Broadband Internalizing Symptoms, but Not Narrowband Positive Affect or Anxious Arousal, in Emerging Adulthood.Clinical psychological science : a journal of the Association for Psychological Science · 2024Article
- Neuroticism/Negative Emotionality Is Associated with Increased Reactivity to Uncertain Threat in the Bed Nucleus of the Stria Terminalis, Not the Amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Fear, anxiety and the functional architecture of the human central extended amygdala.Nature reviews. Neuroscience · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
When extreme, anxiety can become debilitating. Anxiety disorders, which often first emerge early in development, are common and challenging to treat, yet the underlying mechanisms have only recently begun to come into focus. Here, we review new insights into the nature and biological bases of dispositional negativity, a fundamental dimension of childhood temperament and adult personality and a prominent risk factor for the development of pediatric and adult anxiety disorders. Converging lines of epidemiological, neurobiological, and mechanistic evidence suggest that dispositional negativity increases the likelihood of psychopathology via specific neurocognitive mechanisms, including attentional biases to threat and deficits in executive control. Collectively, these observations provide an integrative translational framework for understanding the development and maintenance of anxiety disorders in adults and youth and set the stage for developing improved intervention strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.