Evidence map›Paper›PMID 31196171›Full record

ArticleEpigenetics & chromatin2019

Aberrant methylation-mediated downregulation of lncRNA SSTR5-AS1 promotes progression and metastasis of laryngeal squamous cell carcinoma.

Baoshan Wang, Lei Zhao, Weiwei Chi, Huan Cao, Weina Cui, Wenxia Meng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics & chromatin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 64 citations in OpenAlex.

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  19. LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond.Journal of experimental & clinical cancer research : CR · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Baoshan WangOtolaryngology Head and Neck Surgery Department, The Second Hospital of Hebei Medical University, Heping West Road 215, Shijiazhuang, 050005, Hebei, China. hebwangbs@163.com.
Lei ZhaoOtolaryngology Head and Neck Surgery Department, The Second Hospital of Hebei Medical University, Heping West Road 215, Shijiazhuang, 050005, Hebei, China.
Weiwei ChiOtolaryngology Head and Neck Surgery Department, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Huan CaoOtolaryngology Head and Neck Surgery Department, The Second Hospital of Hebei Medical University, Heping West Road 215, Shijiazhuang, 050005, Hebei, China.
Weina CuiOtolaryngology Head and Neck Surgery Department, The Second Hospital of Hebei Medical University, Heping West Road 215, Shijiazhuang, 050005, Hebei, China.
Wenxia MengOtolaryngology Head and Neck Surgery Department, The Second Hospital of Hebei Medical University, Heping West Road 215, Shijiazhuang, 050005, Hebei, China.
Hebei Medical University · CNSecond Hospital of Hebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLaryngeal squamous cell carcinoma (LSCC) is among the most common malignant tumors with poor prognosis. Accumulating evidences have identified the important roles of long noncoding RNAs (lncRNAs) in the initiation and progression of various cancer types; however, the global lncRNAs expression profile for metastatic LSCC is limited.

resultsIn the present study, we screen expression profiles of lncRNAs in advanced LSCC patients with paired tumor tissues and corresponding normal tissues by microarrays. We identify numerous differentially expressed transcripts, and after the necessary verification of the transcripts expression in expanded samples, we experimentally validate the expression patterns of the remarkable low expressed gene, SSTR5, and its antisense lncRNA, SSTR5-AS1. Downregulation of SSTR5 is detected in LSCC tissues and laryngeal carcinoma cells. Aberrant DNA hypermethylation of the CpG sites clustered in the exon 1 and accumulation of inactive histone modifications at SSTR5 promoter region may be epigenetic mechanisms for its inactivation in LSCC. SSTR5-AS1 may play antitumor role in LSCC and may be regulated by the hypermethylation of the same CpG sites with SSTR5. SSTR5-AS1 inhibits laryngeal carcinoma cells proliferation, migration, and invasion. SSTR5-AS1 increases the enrichment of MLL3 and H3K4me3 at the promoter region of SSTR5 by interacting with MLL3 and further induces the transcription of SSTR5. Furthermore, SSTR5-AS1 interacts with and recruits TET1 to its target gene E-cadherin to activate its expression.

conclusionThese findings suggest that the identified lncRNAs and mRNAs may be potential biomarkers in metastatic LSCC, and SSTR5-AS1 may act as a tumor suppressor as well as a potential biomarker for antitumor therapy.

Indexed as

DNA MethylationAgedCell Line, TumorCell ProliferationDisease ProgressionDown-RegulationFemaleHumansLaryngeal NeoplasmsMaleMiddle AgedMixed Function OxygenasesNeoplasm MetastasisOligoribonucleotides, AntisenseProto-Oncogene ProteinsReceptors, SomatostatinMixed Function OxygenasesOligoribonucleotides, AntisenseProto-Oncogene ProteinsReceptors, SomatostatinRNA, Long Noncodingsomatostatin receptor 5TET1 protein, humanExpressionLaryngeal squamous cell carcinomaMethylationSSTR5SSTR5-AS1

Identifiers

PMID31196171
PMCPMC6563380
OpenAlexW2950869838

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.