Evidence map›Paper›PMID 31196163›Full record

ArticleStem cell research & therapy2019

A preclinical study-systemic evaluation of safety on mesenchymal stem cells derived from human gingiva tissue.

Jun Zhao, Julie Wang, Junlong Dang, Wangyu Zhu, Yaqiong Chen, Ximei Zhang, Junliang Xie, Bo Hu, Feng Huang, Baoqing Sun and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Jun ZhaoDepartment of Clinical Immunology, Third Affiliated Hospital at the Sun Yat-sen University, Guangzhou, China.
Julie WangDivision of Immunology and Rheumatology, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, USA.
Junlong DangDivision of Rheumatology, Department of Medicine, Milton S. Hershey Medical Center, Hershey, USA.
Wangyu ZhuCenter of Immunology, Zhoushan City Hospital at Wenzhou Medical University, Wenzhou, China.
Yaqiong ChenDepartment of Laboratory Medicine, Third Affiliated Hospital at the Sun Yat-sen University, Guangzhou, China.
Ximei ZhangDivision of Immunology and Rheumatology, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, USA.
Junliang XieHuize Biotech, LLC and Huifu Biotech, LLC, Zhoushan, China.
Bo HuDepartment of Laboratory Medicine, Third Affiliated Hospital at the Sun Yat-sen University, Guangzhou, China.
Feng HuangDepartment of Clinical Immunology, Third Affiliated Hospital at the Sun Yat-sen University, Guangzhou, China.
Baoqing SunDepartment of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. sunbaoqing@vip.163.com.
Joseph A BellantiDepartment of Pediatrics and Microbiology-Immunology, Georgetown University Medical Center, Washington DC, USA.
Song Guo ZhengDivision of Immunology and Rheumatology, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, USA. SongGuo.Zheng@osumc.edu.ORCID 0000-0002-5611-4774
Sun Yat-sen University · CNThe Ohio State University · USFirst Affiliated Hospital of Guangzhou Medical University · CNGeorgetown University · USPenn State Milton S. Hershey Medical Center · USWenzhou Medical University · CN

Funding

NIAMS NIH HHS R61 AR073409
6 · The paper itself

Abstract

backgroundMounting evidence has shown that a novel subset of mesenchymal stem cells (MSCs) derived from human gingiva referred to as gingival mesenchymal stem cells (GMSCs) displays a greater immunotherapeutic potential and regenerative repair expression than MSCs obtained from other tissues. However, the safety of the use of transplanted GMSCs in humans remains unclear.

methodsIn this study, we evaluated the safety of GMSCs transplanted into mouse, rat, rabbit, beagle dog, and monkey as well as two animal models of autoimmune diseases.

resultsIn short- and long-term toxicity tests, infused GMSCs had no remarkable adverse effects on hematologic and biochemical indexes, particularly on the major organs such as heart, liver, spleen, and kidney in recipient animals. It was also shown that GMSCs were well tolerated in other assays including hemolysis, vascular, and muscular stimulation, as well as systemic anaphylaxis and passive skin Arthus reaction in animal models. GSMC infusion did not cause any notable side effects on animal models of either autoimmune arthritis or lupus. Significantly, GMSCs most likely play no role in genotoxicity and tumorigenesis. The biological features remained stable for an extended period after cell transfer.

conclusionsGMSCs are safe in various animal models of autoimmunity, even during active disease episodes, especially in monkeys. This study paves a solid road for future clinical trials of GMSCs in patients with autoimmune and inflammatory diseases.

Indexed as

AnaphylaxisAnimalsArthritisAutoimmunityCell DifferentiationDogsFemaleGingivaHaplorhiniHumansMaleMesenchymal Stem CellsMesenchymal Stem Cell TransplantationMiceRabbitsRatsGingival mesenchymal stem cells (GMSCs)Mesenchymal stromal cellSafety

Identifiers

PMID31196163
PMCPMC6567625
OpenAlexW2951856415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.