Evidence map›Paper›PMID 31196160›Full record

ArticleStem cell research & therapy2019

Safety and efficacy of ex vivo expanded CD34

Yu Zhang, Bin Shen, Xin Guan, Meng Qin, Zhihua Ren, Yupo Ma, Wei Dai, Xinxin Ding, Yongping Jiang

Open access · goldAbstract read
In one paragraph

Article in Stem cell research & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. CH02 peptide promotesActa biochimica et biophysica Sinica · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Effect of Small Molecule onFrontiers in cell and developmental biology · 2021
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Yu ZhangBiopharmaceutical R&D Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, 215126, China.
Bin ShenBiopharmaceutical R&D Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, 215126, China.
Xin GuanBiopharmaceutical R&D Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, 215126, China.
Meng QinBiopharmaceutical R&D Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, 215126, China.
Zhihua RenBiopharmaceutical R&D Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, 215126, China.
Yupo MaBiopharmaceutical R&D Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, 215126, China.
Wei DaiBiopharmaceutical R&D Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, 215126, China.
Xinxin DingBiopharmaceutical R&D Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, 215126, China. xding@pharmacy.arizona.edu.
Yongping JiangBiopharmaceutical R&D Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, 215126, China. yjiang@biopharmagen.com.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNBeijing University of Chemical Technology · CNNYU Langone Health · USStony Brook University · USUniversity of Arizona · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHematopoietic stem cell (HSC) transplantation has been widely applied to the treatment of malignant blood diseases. However, limited number of functional HSCs hinders successful transplantation. The purpose of our current study is to develop a new and cost-efficient medium formulation that could greatly enhance the expansion of HSCs while retaining their long-term repopulation and hematopoietic properties for effective clinical transplantation.

methodsEnriched human CD34

resultsHEM could effectively expand human CD34

conclusionsTogether, these findings demonstrate promising potential for the utility of HEM to improve expansion of HSCs for clinical application.

Indexed as

ADP-ribosyl Cyclase 1AnimalsAntigens, CD34Cells, CulturedFemaleFlow CytometryHematopoietic Stem CellsHumansImmunophenotypingIntegrin alpha6Leukocyte Common AntigensMiceMice, SCIDPrimatesThy-1 AntigensADP-ribosyl Cyclase 1Antigens, CD34Integrin alpha6Leukocyte Common AntigensThy-1 AntigensEx vivo expansionHuman cord bloodLong-term HSCNOD/SCID miceNonhuman primatesTransplantation

Identifiers

PMID31196160
PMCPMC6567473
OpenAlexW2952732026

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.