Evidence map›Paper›PMID 31196147›Full record

ArticleTrials2019

The acute effects of aerobic exercise on sleep in patients with depression: study protocol for a randomized controlled trial.

Gavin Brupbacher, Doris Straus, Hildburg Porschke, Thea Zander-Schellenberg, Markus Gerber, Roland von Känel, Arno Schmidt-Trucksäss

2 registry-linked trialsOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03673397 nacompletednot on this map

The Acute Effect of Aerobic Exercise on Sleep in Patients With Depression: a Randomized Controlled Trial

TypeinterventionalSponsorOberwaid AGRan2018 to 2020Enrolled92ConditionsDepression, Sleep, Sleep Disorder, Sleep DisturbanceArmsAerobic exercise, bicycle ergometer
NCT06775548 naenrolling by invitationnot on this mapstarted 2024, after this paper: background citation

Effects of Exercises and Vitamins on Oxidative Stress & Inflammatory Markers Among Patients with Depression

TypeinterventionalSponsorZiauddin UniversityRan2024 to 2025Enrolled116ConditionsDepression DisordersArmsAerobic Exercises + Vitamin E, Resistance Exercises + Vitamin E, Aerobic Exercises + Vitamin D, Resistance Exercises + Vitamin D
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Gavin BrupbacherDivision of Sports and Exercise Medicine, Department of Sport, Exercise and Health, University of Basel, Birsstrasse 320 B, 4052, Basel, Switzerland. gavin.brupbacher@unibas.ch.ORCID http://orcid.org/0000-0002-0140-6614
Doris StrausOBERWAID AG, Rorschacher Strasse 311, 9016, St. Gallen, Switzerland.
Hildburg PorschkeOBERWAID AG, Rorschacher Strasse 311, 9016, St. Gallen, Switzerland.
Thea Zander-SchellenbergDepartment of Psychology, Division of Clinical Psychology and Epidemiology, University of Basel, Basel, Switzerland.
Markus GerberDivision of Sport and Psychosocial Health, Department of Sport, Exercise and Health, University of Basel, Birsstrasse 320 B, 4052, Basel, Switzerland.
Roland von KänelDepartment of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, Culmannstrasse 8, 8091, Zurich, Switzerland.
Arno Schmidt-TrucksässDivision of Sports and Exercise Medicine, Department of Sport, Exercise and Health, University of Basel, Birsstrasse 320 B, 4052, Basel, Switzerland.
University of Basel · CHUniversity of St.Gallen · CHUniversity Hospital of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUnipolar depression is one of the most important mental disorders. Insomnia is a symptom of cardinal importance in depression. It increases the risk to develop depression, negatively affects disease trajectory, is the most common symptom after remission, increases the risk of relapse, and is associated with higher suicide rates. Existing therapies for insomnia in depression have limitations. Further adjuvant therapies are therefore needed. Acute aerobic exercise has been shown to have beneficial effects on sleep in healthy individuals and patients with insomnia. We therefore hypothesize that a single session of aerobic exercise has a positive impact on sleep in patients with unipolar depression. This trial aims to investigate the effects of a single bout of aerobic exercise on the subsequent night's sleep in patients with depression. METHODS/

designThis is a two-arm parallel group, randomized, outcome assessor blinded, controlled, superiority trial. Patients between 18 and 65 years of age with a primary diagnosis of unipolar depression (without a psychotic episode) are included. Exclusion criteria are regular use of hypnotic agents, opioids, and certain beta-blockers, as well as the presence of factors precluding exercise, history of epilepsy, restless legs syndrome, moderate obstructive sleep apnea, and a BMI > 40. The intervention is a single bout of aerobic exercise, performed for 30 min on a bicycle ergometer at 80% individual anaerobic threshold. The control group sits and reads for 30 min. The primary outcome is sleep efficiency measured by polysomnography. Secondary outcomes include further polysomnographic variables, subjective pre-sleep arousal, nocturnal cardiovascular autonomic modulation, subjective sleep quality, daytime sleepiness, and adverse events. According to the sample size calculation, a total of 92 patients will be randomized using minimization. DISCUSSION: This trial will add new information to the body of knowledge concerning the treatment of insomnia in patients with depression. Thereby, the results will inform decision makers on the utility of acute aerobic exercise.

trial registrationClinicaltrials.gov, NCT03673397 . Protocol version 1 registered on 17 September 2018.

Indexed as

ExerciseRandomized Controlled Trials as TopicAdultAgedData ManagementDepressionEquivalence Trials as TopicHeart RateHumansMiddle AgedOutcome Assessment, Health CarePolysomnographySleepBlood pressureDepressionExerciseHeart rate variabilityPolysomnographyProtocolRandomized controlled trialSleep

Identifiers

PMID31196147
PMCPMC6567535
OpenAlexW2949692114

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.