ArticleBMC complementary and alternative medicine2019
Modulation of neurological pathways by Salvia officinalis and its dependence on manufacturing process and plant parts used.
Article in BMC complementary and alternative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Exploring nature's hidden treasure: Unraveling the untapped phytochemical and pharmacological potentials ofHeliyon · 2024Review
- The Different Phytochemical Profiles ofMolecules (Basel, Switzerland) · 2023Article
- Neuroprotective Natural Products' Regulatory Effects on Depression via Gut-Brain Axis Targeting Tryptophan.Nutrients · 2022Review
- Neuroprotective Potential of Aromatic Herbs: Rosemary, Sage, and Lavender.Frontiers in neuroscience · 2022Review
- Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis.International journal of molecular sciences · 2021Review
- Effectiveness of Menosan®Heliyon · 2021Article
- A Nutraceutical Approach to Menopausal Complaints.Medicina (Kaunas, Lithuania) · 2019Review
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Authors and funding
2 authors.
Funding
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Abstract
backgroundSalvia officinalis has been used successfully for the treatment of hot flushes and excessive sweating during menopause. However, modes of actions have not been elucidated conclusively. We explored its pharmacology beyond any hormonal activity with a focus on neurologic impulse transmission.
methodsA hydroalcoholic, thujone-free extract from freshly harvested Salvia officinalis leaves (A.Vogel Menosan®) was investigated in an acetylcholinesterase enzyme assay and several receptor binding assays (adrenergic alpha 2A, GABA (benzodiazepine site), GABA
resultsThe Salvia officinalis extract replaced 50% of specific ligand binding to GABA
conclusionOur results suggest potent modulation of neuro-receptors and of serotonin transporters as mode of action for Salvia officinalis alcoholic extract, which may normalize thermoregulation and possibly also mental impairment during menopause.
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