Evidence map›Paper›PMID 31195990›Full record

ArticleBMC gastroenterology2019

The association of hepatitis c virus infection status with serum glucose levels.

Yinping Li, Xiaomei Wang, Ge Yu, Haibo Sun, Juan Lv, Xiumei Chi, Ruihong Wu, Xiuzhu Gao, Junqi Niu

Open access · goldAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Review
  5. Metabolic complications of hepatitis C virus infection.World journal of gastroenterology · 2021
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yinping LiDepartment of Hepatology, the First hospital of Jilin University, No.71 Xinmin Str, Changchun, 130021, China.
Xiaomei WangDepartment of Hepatology, the First hospital of Jilin University, No.71 Xinmin Str, Changchun, 130021, China.
Ge YuDepartment of Hepatology, the First hospital of Jilin University, No.71 Xinmin Str, Changchun, 130021, China.
Haibo SunDepartment of Hepatology, the First hospital of Jilin University, No.71 Xinmin Str, Changchun, 130021, China.
Juan LvDepartment of Hepatology, the First hospital of Jilin University, No.71 Xinmin Str, Changchun, 130021, China.
Xiumei ChiDepartment of Hepatology, the First hospital of Jilin University, No.71 Xinmin Str, Changchun, 130021, China.
Ruihong WuDepartment of Hepatology, the First hospital of Jilin University, No.71 Xinmin Str, Changchun, 130021, China.
Xiuzhu GaoDepartment of Hepatology, the First hospital of Jilin University, No.71 Xinmin Str, Changchun, 130021, China.
Junqi NiuDepartment of Hepatology, the First hospital of Jilin University, No.71 Xinmin Str, Changchun, 130021, China. junqi_niu@163.com.
Jilin University · CNFirst Hospital of Jilin University · CNMinistry of Education of the People's Republic of China · CN

Funding

the National Basic Research Program of China 2015CB554300the National Natural Science Foundation of China 81301472
6 · The paper itself

Abstract

backgroundHepatitis C virus (HCV) infection is commonly associated with a disturbance of glucose metabolism. However, there have been conflicting reports on whether the clearance of the HCV may be followed by changes of serum blood glucose and insulin resistance. The aim of the present study was to evaluate the impact of HCV and antiviral treatment on serum glucose levels and other glucose metabolism parameters.

methodsA retrospective analysis of 306 HCV-infected patients was performed. Fasting serum blood glucose (FBG) levels in these patients were compared with that of 325 healthy individuals. Serum parameters of glucose metabolism were measured in 183 patients with chronic hepatitis C at baseline, at the end of interferon α-2b plus ribavirin treatment, and at 24 weeks post-treatment.

resultsPatients with HCV infection had significantly higher FBG level than healthy controls (5.57 ± 0.74 vs. 5.11 ± 0.83 mmol/l, P < 0.001). After antiviral treatment, we found a significant reduction in FBG levels regardless of the outcome of treatment. However, after stopping treatment the serum FBG levels were significantly elevated in the sustained virological response (SVR) and non-responder groups, and maintained high level until week 24 post-treatment. In both groups, the levels of serum FBG after 24 weeks post-treatment were still lower than pre-treatment levels. In sustained responders, fasting insulin (P = 0.007), C-peptide (P < 0.001) and HOMA-IR (P < 0.001) significantly decreased, and the insulin sensitivity index (ISI) increased (P < 0.001) at the end of the treatment comparing with pre-treatment levels, while no significant difference was observed in non-responder group. HOMA-β values were increased in both groups at the end of treatment (both P < 0.001).

conclusionThe total serum FBG level in HCV infected patients was higher than that in healthy controls. Clearance of HCV was associated with reduced glucose and improved insulin resistance.

Indexed as

HepacivirusInsulin ResistanceAdultAntiviral AgentsBlood GlucoseDrug Therapy, CombinationFastingFemaleHepatitis C, ChronicHumansInsulinInterferon-alphaMaleMiddle AgedRetrospective StudiesRibavirinAntiviral AgentsBlood GlucoseInsulinInterferon-alphaRibavirinAntiviral treatmentChronic hepatitis CFasting blood glucoseSustained virological response

Identifiers

PMID31195990
PMCPMC6567554
OpenAlexW2950592958

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.