Evidence map›Paper›PMID 31195730›Full record

ArticleNanomaterials (Basel, Switzerland)2019

A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro.

Ji Chen, Guotao Li, Qihong Liu, Yan Liang, Miaochang Liu, Huayue Wu, Wenxia Gao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. RSC advances · 2020
    Article
  4. Visible Light Driven Heterojunction Photocatalyst of CuO-CuNanomaterials (Basel, Switzerland) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ji ChenCollege of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China. 16451282234@stu.wzu.edu.cn.
Guotao LiCollege of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China. chemliguotao@sina.com.
Qihong LiuCollege of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China. qihong.liu@pharmaron-bj.com.
Yan LiangDepartment of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao 266021, China. liangyan@qdu.edu.cn.
Miaochang LiuCollege of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China. mcl@wzu.edu.cn.
Huayue WuCollege of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China. huayuewu@wzu.edu.cn.
Wenxia GaoCollege of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China. wenxiag@wzu.edu.cn.

Funding

National Natural Science Foundation of China 21672164
6 · The paper itself

Abstract

Accelerating degradation of prodrug is an effective strategy for improving the pharmacological action. A photocleavable amphiphilic prodrug of methotrexate-coumarin derivative-PEG conjugates (MTX-AMC-PEG) with photo-triggered breakage to release clinical drug under laser irradiation was fabricated and self-assembled into nanoparticles for chemotherapy. The nanoparticles exhibited good intracellular uptake and excellent photolysis release of MTX, which resulted in efficient anticancer activity in vitro with laser irradiation. This research provides a way to fabricate photocleavable prodrug nanoparticles with stimuli-triggered drug release behavior.

Indexed as

chemotherapymethotrexatephotocleavableprodrugstimuli-responsive release

Identifiers

PMID31195730
PMCPMC6630543

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.