Evidence map›Paper›PMID 31195717›Full record

ArticlePolymers2019

Plasma Polymerized Allylamine-The Unique Cell-Attractive Nanolayer for Dental Implant Materials.

J Barbara Nebe, Henrike Rebl, Michael Schlosser, Susanne Staehlke, Martina Gruening, Klaus-Dieter Weltmann, Uwe Walschus, Birgit Finke

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. The dental implant surface: a review of the past, present and future.Journal of materials science. Materials in medicine · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. The nanomorphology of cell surfaces of adhered osteoblasts.Beilstein journal of nanotechnology · 2021
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

J Barbara NebeDepartment of Cell Biology, Rostock University Medical Center, Schillingallee 69, 18057 Rostock, Germany. barbara.nebe@med.uni-rostock.de.
Henrike ReblDepartment of Cell Biology, Rostock University Medical Center, Schillingallee 69, 18057 Rostock, Germany. henrike.rebl@med.uni-rostock.de.
Michael SchlosserDepartment of Surgery, University Medical Center Greifswald, 17475 Greifswald, Germany. schlosse@uni-greifswald.de.
Susanne StaehlkeDepartment of Cell Biology, Rostock University Medical Center, Schillingallee 69, 18057 Rostock, Germany. susanne.staehlke@med.uni-rostock.de.
Martina GrueningDepartment of Cell Biology, Rostock University Medical Center, Schillingallee 69, 18057 Rostock, Germany. martina.gruening@med.uni-rostock.de.
Klaus-Dieter WeltmannLeibniz Institute for Plasma Science and Technology (INP), Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany. weltmann@inp-greifswald.de.
Uwe WalschusDepartment of Medical Biochemistry and Molecular Biology, University Medical Center Greifswald, 17475 Greifswald, Germany. uwe.walschus@uni-greifswald.de.
Birgit FinkeLeibniz Institute for Plasma Science and Technology (INP), Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany. finke-hgw@t-online.de.
University of Rostock · DELeibniz Institute for Plasma Science and Technology · DEUniversitätsmedizin Greifswald · DE

Funding

Bundesministerium für Bildung und Forschung 13N11183, 13N11188, 13N9779, 13N9775Deutsche Forschungsgemeinschaft 1270Deutsche Forschungsgemeinschaft NE560/3-4Helmholtz-Gemeinschaft UR0402210
6 · The paper itself

Abstract

Biomaterials should be bioactive in stimulating the surrounding tissue to accelerate the ingrowth of permanent implants. Chemical and topographical features of the biomaterial surface affect cell physiology at the interface. A frequently asked question is whether the chemistry or the topography dominates the cell-material interaction. Recently, we demonstrated that a plasma-chemical modification using allylamine as a precursor was able to boost not only cell attachment and cell migration, but also intracellular signaling in vital cells. This microwave plasma process generated a homogenous nanolayer with randomly distributed, positively charged amino groups. In contrast, the surface of the human osteoblast is negatively charged at -15 mV due to its hyaluronan coat. As a consequence, we assumed that positive charges at the material surface-provoking electrostatic interaction forces-are attractive for the first cell encounter. This plasma-chemical nanocoating can be used for several biomaterials in orthopedic and dental implantology like titanium, titanium alloys, calcium phosphate scaffolds, and polylactide fiber meshes produced by electrospinning. In this regard, we wanted to ascertain whether plasma polymerized allylamine (PPAAm) is also suitable for increasing the attractiveness of a ceramic surface for dental implants using Yttria-stabilized tetragonal zirconia.

Indexed as

actin cytoskeletoncell adhesioncell signalingosteoblastsplasma polymerized allylaminesurface characteristicswater contact angleXPSzeta potentialzirconia

Identifiers

PMID31195717
PMCPMC6631006
OpenAlexW2948203400

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.