ArticleJournal of clinical medicine2019
Metabolomic Investigation of β-Thalassemia in Chorionic Villi Samples.
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Serum Metabolomic Signatures Indicate Oxidative Membrane Lipid Remodeling in β-Thalassemia.Metabolites · 2026Article
- Prevalence of low bone mineral density and associated plasma metabolite alterations in thalassemia.Scientific reports · 2026Article
- Assessing oxidative stress in foetuses with β-globin gene mutations.The Indian journal of medical research · 2025Article
- Metabolomics Study of Serum Samples of β-YAC Transgenic Mice Treated with Tenofovir Disoproxil Fumarate.International journal of molecular sciences · 2022Article
- Amniotic fluid metabolomic and lipidomic alterations associated with hemoglobin Bart's diseases.Metabolomics : Official journal of the Metabolomic Society · 2021Article
- Metabolomics Analysis of Amniotic Fluid in Euploid Foetuses with Thickened Nuchal Translucency by Gas Chromatography-Mass Spectrometry.Life (Basel, Switzerland) · 2021Article
- Identification of Circulating Endocan-1 and Ether Phospholipids as Biomarkers for Complications in Thalassemia Patients.Metabolites · 2021Article
- Metabolomics in Prenatal Medicine: A Review.Frontiers in medicine · 2021Review
- Proteomics and metabolomics analysis reveal potential mechanism of extended-spectrum β-lactamase production inRSC advances · 2020Article
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Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBeta-thalassemias are blood disorders characterized by poorly understood clinical phenotypes ranging from asymptomatic to severe anemia. Metabolic composition of the human placenta could be affected by the presence of pathological states such as β-thalassemia. The aim of our study was to describe metabolic changes in chorionic villi samples of fetuses affected by β-thalassemia compared to a control group by applying a metabolomics approach.
methodsChorionic villi samples were differentiated according to the genetic diagnosis of β-thalassemia: control (Group 1,
resultsSupervised multivariate models were devised to compare the groups. The model resulting from the comparison between Group 1 and Group 3 was the most significant. Discriminant metabolites were identified, and the most altered pathways were as follows: pentose phosphate pathway (PPP), arachidonic acid metabolism, glycolysis, and gluconeogenesis, suggesting the presence of an energetic shift toward the PPP and the presence of oxidative stress in β-thalassemia chorionic villi samples.
conclusionsThe metabolomics approach identified a specific metabolic fingerprint in chorionic villi of fetuses affected by β-thalassemia.
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