Evidence map›Paper›PMID 31195666›Full record

ArticleVeterinary sciences2019

2,4-Thiazolidinedione in Well-Fed Lactating Dairy Goats: II. Response to Intra-Mammary Infection.

Fernanda Rosa, Misagh Moridi, Johan S Osorio, Jayant Lohakare, Erminio Trevisi, Shelby Filley, Charles Estill, Massimo Bionaz

Abstract read
In one paragraph

Article in Veterinary sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fernanda RosaDepartment of Animal and Rangeland Sciences, Oregon State University, Corvallis, OR 97331, USA. Fernanda.Rosa@sdstate.edu.
Misagh MoridiDepartment of Animal Science, University of Guilan, Kilometer 5 of Rasht-Qazvin Highway, Rasht 4199613776, Iran. moridimisagh64@gmail.com.
Johan S OsorioDepartment of Animal and Rangeland Sciences, Oregon State University, Corvallis, OR 97331, USA. Johan.Osorio@sdstate.edu.
Jayant LohakareDepartment of Animal Biotechnology, Kangwon National University, KNU Ave 1, Chuncheon 200-701, Korea. lohakarej@uapb.edu.
Erminio TrevisiDepartment of Animal Sciences, Food and Nutrition (DIANA), Università Cattolica del Sacro Cuore, Via Emilia Parmense, 84, 29122 Piacenza PC, Italy. erminio.trevisi@unicatt.it.ORCID 0000-0003-1644-1911
Shelby FilleyDepartment of Animal and Rangeland Sciences, Oregon State University, Corvallis, OR 97331, USA. shelby.filley@oregonstate.edu.
Charles EstillDepartment of Animal and Rangeland Sciences, Oregon State University, Corvallis, OR 97331, USA. Charles.Estill@oregonstate.edu.
Massimo BionazDepartment of Animal and Rangeland Sciences, Oregon State University, Corvallis, OR 97331, USA. massimo.bionaz@oregonstate.edu.ORCID 0000-0002-0674-1892

Funding

Oregon Beef Council N/A
6 · The paper itself

Abstract

In a prior experiment, treatment of goats with the putative PPARγ agonist 2,4-thiazolidinedione (2,4-TZD) ameliorated the response to intramammary infection without evidence of PPARγ activation. The lack of PPARγ activation was possibly due to deficiency of vitamin A and/or a poor body condition of the animals. Therefore, the present study hypothesized that activation of PPARγ by 2,4-TZD in goats supplemented with adequate amounts of vitamin A can improve the response to sub-clinical mastitis. Lactating goats receiving a diet that met National Research Council requirements, including vitamin A, were injected with 8 mg/kg BW of 2,4-TZD (

Indexed as

2,4-thiazolidinedionegoatmacrophagesmammary epithelial cellsmastitis

Identifiers

PMID31195666
PMCPMC6632143

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.