ReviewInternational journal of molecular sciences2019
Mitochondrial Activity and Skeletal Muscle Insulin Resistance in Kidney Disease.
Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- Triglyceride-Glucose Index and Acute Kidney Injury: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Estimated glucose processing rates and the association of chronic kidney disease and proteinuria in non-diabetic adults.International urology and nephrology · 2025Article
- Influence of metabolism-related comorbidities and insulin resistance on new onset of chronic kidney disease in a health check-up population: a two-stage retrospective cohort study.BMJ open diabetes research & care · 2025Article
- Estimated glucose disposal rate for predicting cardiovascular events and mortality in patients with non-diabetic chronic kidney disease: a prospective cohort study.BMC medicine · 2024Article
- Sex hormone binding globulin (SHBG) serum levels and insulin resistance in men on chronic hemodialysis.Diabetology & metabolic syndrome · 2024Article
- Interdialytic home systolic blood pressure variability increases all-cause mortality in hemodialysis patients.Clinical cardiology · 2024Article
- Mitochondrial disorders as a mechanism for the development of obese Sarcopenia.Diabetology & metabolic syndrome · 2023Review
- Brain-derived neurotrophic factor associated with kidney function.Diabetology & metabolic syndrome · 2023Article
- Indoxyl sulfate mediates low handgrip strength and is predictive of high hospitalization rates in patients with end-stage renal disease.Frontiers in medicine · 2023Article
- TLR13 contributes to skeletal muscle atrophy by increasing insulin resistance in chronic kidney disease.Cell proliferation · 2022Article
- Article
- Role of exosomes and exosomal microRNA in muscle-Kidney crosstalk in chronic kidney disease.Frontiers in cell and developmental biology · 2022Review
- Mechanism ofFrontiers in pharmacology · 2022Article
- Berberine Improves the Protective Effects of Metformin on Diabetic Nephropathy in db/db Mice through Trib1-dependent Inhibiting Inflammation.Pharmaceutical research · 2021Article
- The role of IL-1 in adipose browning and muscle wasting in CKD-associated cachexia.Scientific reports · 2021Article
- Article
- [Correlation between sarcopenia and albuminuria in patients with type 2 diabetes].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- Article
- Mitochondrial DNA: A New Predictor of Diabetic Kidney Disease.International journal of endocrinology · 2020Review
- Dysbiosis of intestinal microbiota mediates tubulointerstitial injury in diabetic nephropathy via the disruption of cholesterol homeostasis.Theranostics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Insulin resistance is a key feature of the metabolic syndrome, a cluster of medical disorders that together increase the chance of developing type 2 diabetes and cardiovascular disease. In turn, type 2 diabetes may cause complications such as diabetic kidney disease (DKD). Obesity is a major risk factor for developing systemic insulin resistance, and skeletal muscle is the first tissue in susceptible individuals to lose its insulin responsiveness. Interestingly, lean individuals are not immune to insulin resistance either. Non-obese, non-diabetic subjects with chronic kidney disease (CKD), for example, exhibit insulin resistance at the very onset of CKD, even before clinical symptoms of renal failure are clear. This uraemic insulin resistance contributes to the muscle weakness and muscle wasting that many CKD patients face, especially during the later stages of the disease. Bioenergetic failure has been associated with the loss of skeletal muscle insulin sensitivity in obesity and uraemia, as well as in the development of kidney disease and its sarcopenic complications. In this mini review, we evaluate how mitochondrial activity of different renal cell types changes during DKD progression, and discuss the controversial role of oxidative stress and mitochondrial reactive oxygen species in DKD. We also compare the involvement of skeletal muscle mitochondria in uraemic and obesity-related muscle insulin resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.