Evidence map›Paper›PMID 31194918›Full record

ArticleAmerican journal of respiratory cell and molecular biology2020

Apolipoprotein E and Periostin Are Potential Biomarkers of Nasal Mucosal Inflammation. A Parallel Approach of

Youn Wook Chung, Jimin Cha, Seunghan Han, Yong Chen, Marjan Gucek, Hyung-Ju Cho, Kiichi Nakahira, Augustine M K Choi, Ji-Hwan Ryu, Joo-Heon Yoon

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Antioxidants (Basel, Switzerland) · 2022
    Article
  8. Review
  9. Article
  10. Update in Adult Asthma 2020.American journal of respiratory and critical care medicine · 2021
    Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Youn Wook ChungThe Airway Mucus Institute.
Jimin ChaSeverance Biomedical Science Institute.
Seunghan HanSeverance Biomedical Science Institute.
Yong ChenProteomics Core Facility, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland; and.
Marjan GucekProteomics Core Facility, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland; and.
Hyung-Ju ChoThe Airway Mucus Institute.
Kiichi NakahiraDivision of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, New York.
Augustine M K ChoiDivision of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, New York.
Ji-Hwan RyuSeverance Biomedical Science Institute.
Joo-Heon YoonThe Airway Mucus Institute.
Korea Institute of Brain Science · KRCornell University · USNational Institutes of Health · USYonsei University · KR

Funding

Respiratory Computational Discovery CoreP01HL114501 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHOI, MARY E · 2013 to 2025
$24.9M
Proteomics CoreZICHL005903 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI GUCEK, MARJAN · 2009 to 2022
$23.3M
NHLBI NIH HHS P01 HL114501
6 · The paper itself

Abstract

No previously suggested biomarkers of nasal mucosal inflammation have been practically applied in clinical fields, and nasal epithelium-derived secreted proteins as biomarkers have not specifically been investigated. The goal of this study was to identify secreted proteins that dynamically change during the differentiation from basal cells to fully differentiated cells and examine whether nasal epithelium-derived proteins can be used as biomarkers of nasal mucosal inflammation, such as chronic rhinosinusitis. To achieve this goal, we analyzed two secretomes using the isobaric tag for relative and absolute quantification technique. From

Indexed as

Apolipoproteins EBiomarkersCell Adhesion MoleculesChronic DiseaseEpithelial CellsFemaleHumansInflammationMaleNasal Lavage FluidNasal MucosaNasal PolypsRhinitisSinusitisApolipoproteins EBiomarkersCell Adhesion MoleculesPOSTN protein, humanair–liquid interface culturemucosal secretionsnasal epitheliumsecreted proteinssecretome

Identifiers

PMID31194918
PMCPMC7051477
OpenAlexW2952208629

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.