Evidence map›Paper›PMID 31194860›Full record

ArticleJournal of the Pediatric Infectious Diseases Society2020

Association of Virologic Failure and Nonnucleoside Reverse Transcriptase Inhibitor Resistance Found in Antiretroviral-Naive Children Infected With Human Immunodeficiency Virus and Given Efavirenz-Based Treatment.

Nikki Higa, Amy Pelz, Donald Birch, Ingrid A Beck, Tatiana Sils, Pearl Samson, Mutsawashe Bwakura-Dangarembizi, Carolyn Bolton-Moore, Edmund Capparelli, Ellen Chadwick and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the Pediatric Infectious Diseases Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Nikki HigaSeattle Children's Research Institute, Washington.
Amy PelzSeattle Children's Research Institute, Washington.
Donald BirchSeattle Children's Research Institute, Washington.
Ingrid A BeckSeattle Children's Research Institute, Washington.
Tatiana SilsSeattle Children's Research Institute, Washington.
Pearl SamsonHarvard T. H. Chan School of Public Health, Boston, Massachusetts.
Mutsawashe Bwakura-DangarembiziUniversity of Zimbabwe College of Health Sciences, Harare.
Carolyn Bolton-MooreCentre for Infectious Disease Research in Zambia, Lusaka.
Edmund CapparelliUniversity of California, San Diego, La Jolla.
Ellen ChadwickNorthwestern University Feinberg School of Medicine, Chicago, Illinois.
Lisa M FrenkelSeattle Children's Research Institute, Washington.
Centre for Infectious Disease Research in Zambia · ZMHarvard University · USNorthwestern University · USUniversity of California, San Diego · USUniversity of Washington · USUniversity of Zimbabwe · ZW

Funding

Statistical and Data Management Center (SDMC), AIDS Clinical Trials Group (ACTG)UM1AI068634 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Marlene Ann Cooper, Michael David Hughes · 2011 to 2026
$246.6M
Statistical and Data Management Center-Pediatric,Adolescent, and Maternal CTGUM1AI068616 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Sean Scott Brummel, Marlene Ann Cooper · 2011 to 2026
$155.6M
University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
NIAID NIH HHS P30 AI027757NIAID NIH HHS UM1 AI068616NIAID NIH HHS UM1 AI068634
6 · The paper itself

Abstract

Among 66 antiretroviral-naive children aged <3 years with human immunodeficiency virus (HIV) or coinfected with HIV and tuberculosis and initiating efavirenz-based antiretroviral therapy (ART), non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance was detected before ART in 5 (7.6%). Virologic failure occurred in 2 of these children; they were last tested at 16 and 24 weeks of ART. Pre-ART NNRTI resistance was not associated with virologic failure.

Indexed as

HIV-1AIDS-Related Opportunistic InfectionsAlkynesAnti-Retroviral AgentsBenzoxazinesChild, PreschoolCyclopropanesDrug Resistance, ViralFemaleGenotypeHIV InfectionsHumansInfantMaleMutationPolymerase Chain ReactionAlkynesAnti-Retroviral AgentsBenzoxazinesCyclopropanesefavirenzReverse Transcriptase InhibitorsRNA, ViralefavirenzHIV drug resistanceHIV-infected childrenHIV/TB coinfectionNNRTI resistance

Identifiers

PMID31194860
PMCPMC7192398
OpenAlexW2950085171

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.