ArticlePloS one2019
Emergence of an Australian-like pstS-null vancomycin resistant Enterococcus faecium clone in Scotland.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Sentinel Surveillance reveals phylogenetic diversity and detection of linear plasmids harboringAntimicrobial agents and chemotherapy · 2024Article
- Enterococcus faecium: evolution, adaptation, pathogenesis and emerging therapeutics.Nature reviews. Microbiology · 2024Review
- Genetic analysis of vancomycin-variable Enterococcus faecium clinical isolates in Italy.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Article
- Integration of vanHAX downstream of a ribosomal RNA operon restores vancomycin resistance in a susceptible Enterococcus faecium strain.npj antimicrobials and resistance · 2024Article
- New Multilocus Sequence Typing Scheme for Enterococcus faecium Based on Whole Genome Sequencing Data.Microbiology spectrum · 2023Article
- An Economic Evaluation Estimating the Clinical and Economic Burden of Increased Vancomycin-Resistant Enterococcus faecium Infection Incidence in Japan.Infectious diseases and therapy · 2023Article
- Interhospital transmission of vancomycin-resistant Enterococcus faecium in Aomori, Japan.Antimicrobial resistance and infection control · 2022Article
- Centre-specific bacterial pathogen typing affects infection-control decision making.Microbial genomics · 2021Article
- The Role of Whole Genome Sequencing in the Surveillance of Antimicrobial ResistantFrontiers in public health · 2021Article
- Emergence of pstS-Null Vancomycin-Resistant Enterococcus faecium Clone ST1478, Canada, 2013-2018.Emerging infectious diseases · 2020Article
- Emergence of vancomycin-resistant Enterococcus faecium ST1421 lacking the pstS gene in Korea.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Article
- State-Wide Genomic and Epidemiological Analyses of Vancomycin-ResistantFrontiers in microbiology · 2019Article
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5 authors.
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Abstract
Multi-locus sequencing typing (MLST) is widely used to monitor the phylogeny of microbial outbreaks. However, several strains of vancomycin-resistant Enterococcus faecium (VREfm) with a missing MLST locus (pstS) have recently emerged in Australia, with a few cases also reported in England. Here, we identified similarly distinct strains circulating in two neighbouring hospitals in Scotland. Whole genome sequencing of five VREfm strains isolated from these hospitals identified four pstS-null strains in both hospitals, while the fifth was multi-locus sequence type (ST) 262, which is the first documented in the UK. All five Scottish isolates had an insertion in the tetM gene, which is associated with increased susceptibility to tetracyclines, providing no other tetracycline-resistant gene is present. Such an insertion, which encompasses a dfrG gene and two currently uncharacterised genes, was additionally identified in all tested vanA-type pstS-null VREfm strains (5 English and 68 Australian). Phylogenetic comparison with other VREfm genomes indicates that the four pstS-null Scottish isolates sequenced in this study are more closely related to pstS-null strains from Australia rather than the English pstS-null isolates. Given how rapidly such pstS-null strains have expanded in Australia, the emergence of this clone in Scotland raises concerns for a potential outbreak.
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