ArticlePLoS genetics2019
Essential long-range action of Wingless/Wnt in adult intestinal compartmentalization.
Article in PLoS genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
- Systematic generation ofFly · 2026Article
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- Matrix metalloproteinase 2 destabilizes Dally-like protein to restrict extracellular Wingless distribution.Molecular biology of the cell · 2025Article
- Mechanistic insights into Wnt-β-catenin pathway activation and signal transduction.Nature reviews. Molecular cell biology · 2025Review
- Contact area and tissue growth dynamics shape synthetic juxtacrine signaling patterns.Biophysical journal · 2025Article
- The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6.Nature communications · 2023Article
- Identification and characterization of stem cells in mammalian esophageal stratified squamous epithelia.Journal of molecular cell biology · 2022Article
- Insect Gut Regeneration.Cold Spring Harbor perspectives in biology · 2022Review
- Regulation of Wnt distribution and function by Drosophila glypicans.Journal of cell science · 2022Review
- Article
- Early patterning followed by tissue growth establishes distal identity inFrontiers in cell and developmental biology · 2022Article
- Asymmetric requirement of Dpp/BMP morphogen dispersal in the Drosophila wing disc.Nature communications · 2021Article
- Pluripotency state regulates cytoneme selectivity and self-organization of embryonic stem cells.The Journal of cell biology · 2021Article
- Extracellular spreading of Wingless is required for Drosophila oogenesis.PLoS genetics · 2021Article
- Wg secreted by conventional Golgi transport diffuses and forms Wg gradient whereas Wg tethered to extracellular vesicles do not diffuse.Cell death and differentiation · 2021Article
- A unified mechanism for the control of Drosophila wing growth by the morphogens Decapentaplegic and Wingless.PLoS biology · 2021Article
- The Emerging Mechanisms of Wnt Secretion and Signaling in Development.Frontiers in cell and developmental biology · 2021Review
- Extracellular WNTs: Trafficking, Exosomes, and Ligand-Receptor Interaction.Handbook of experimental pharmacology · 2021Review
- Article
- Review
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4 authors at 1 institution in 1 country.
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Abstract
Signal transduction activated by Wingless/Wnt ligands directs cell proliferation and fate specification in metazoans, and its overactivation underlies the development of the vast majority of colorectal cancers. In the conventional model, the secretion and movement of Wingless to cells distant from its source of synthesis are essential for long-range signaling in tissue patterning. However, this model was upended recently by an unanticipated finding: replacement of wild-type Drosophila Wingless with a membrane-tethered form produced viable adults with largely normal external morphology, which suggested that Wingless secretion and movement are dispensable for tissue patterning. Herein, we tested this foundational principle in the adult intestine, where Wingless signaling gradients coincide with all major boundaries between compartments. We find that the critical roles of Wingless during adult intestinal development, which include regulation of target gene activation, boundary formation, stem cell proliferation, epithelial cell fate specification, muscle differentiation, gut folding, and signaling crosstalk with the Decapentaplegic pathway, are all disrupted by Wingless tethering. These findings provide new evidence that supports the requirement for the direct, long-range action of Wingless in tissue patterning, with relevance for animal development, tissue homeostasis and Wnt-driven disease.
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