ArticleMMWR. Morbidity and mortality weekly report2019
Sepsis Attributed to Bacterial Contamination of Platelets Associated with a Potential Common Source - Multiple States, 2018.
Article in MMWR. Morbidity and mortality weekly report, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The trial behind it
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Who cites it
26 citing papers in PubMed, 59 citations in OpenAlex.
- Nonmyeloablative HLA-identical sibling transplant for sickle cell disease in children: a multicenter prospective study.Blood advances · 2026Trial
- Assessment of the efficacy of large volume delayed sampling primary culture and pathogen reduction in preventing septic reactions from platelet transfusions.Transfusion · 2026Review
- Consideration in Platelet Transfusion-Transmitted Klebsiella pneumoniae Sepsis: A Case Report.Cureus · 2026Article
- Monitoring bacterial contamination of blood components at the Croatian Institute of Transfusion Medicine-Evolution of strategies and results in a 14-year period (2011-2024).Vox sanguinis · 2026Article
- Practices in platelet production: A Nordic perspective (2018-2022).Vox sanguinis · 2026Article
- Monitoring of Staphylococcus epidermidis biofilm formation on platelet storage bag surfaces.PloS one · 2025Article
- Formation of Single-Species and Multispecies Biofilm by Isolates from Septic Transfusion Reactions in Platelet Bag Model.Emerging infectious diseases · 2024Article
- Bacterial Contamination of Platelet Products.Microorganisms · 2024Review
- Posttransfusion sepsis attributable to bacterial contamination in platelet collection set manufacturing, United States.Transfusion · 2023Article
- Changing Strategies for the Detection of Bacteria in Platelet Components in Ireland: From Primary and Secondary Culture (2010-2020) to Large Volume Delayed Sampling (2020-2023).Microorganisms · 2023Article
- Posttransfusion Sepsis Attributable to Bacterial Contamination in Platelet Collection Set Manufacturing Facility, United States.Emerging infectious diseases · 2023Review
- Article
- Platelet components and bacterial contamination: hospital perspective 2022.Hematology. American Society of Hematology. Education Program · 2022Article
- Assessment of polymicrobial interactions in bacterial isolates from transfused platelet units associated with sepsis.Transfusion · 2022Article
- Acquired platelet storage container leaks and contamination with environmental bacteria: A preventable cause of bacterial sepsis.Transfusion · 2022Article
- Economic implications of FDA platelet bacterial guidance compliance options: Comparison of single-step strategies.Transfusion · 2022Article
- Evaluation of an improved rapid bacterial assay with untreated and pathogen-reduced platelets: Detection of Acinetobacter strains.Transfusion · 2021Article
- A Comparison of Transfusion-Related Adverse Reactions Among Apheresis Platelets, Whole Blood-Derived Platelets, and Platelets Subjected to Pathogen Reduction Technology as Reported to the National Healthcare Safety Network Hemovigilance Module.Transfusion medicine reviews · 2021Review
- Performance profile of an updated safety measure rapid assay for bacteria in platelets.Transfusion · 2020Article
- Investigating Transfusion-related Sepsis Using Culture-Independent Metagenomic Sequencing.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
Corrections and comments
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Authors and funding
34 authors.
Funding
Abstract
During May-October 2018, four patients from three states experienced sepsis after transfusion of apheresis platelets contaminated with Acinetobacter calcoaceticus-baumannii complex (ACBC) and Staphylococcus saprophyticus; one patient died. ACBC isolates from patients' blood, transfused platelet residuals, and two environmental samples were closely related by whole genome sequencing. S. saprophyticus isolates from two patients' blood, three transfused platelet residuals, and one hospital environmental sample formed two whole genome sequencing clusters. This whole genome sequencing analysis indicated a potential common source of bacterial contamination; investigation into the contamination source continues. All platelet donations were collected using apheresis cell separator machines and collection sets from the same manufacturer; two of three collection sets were from the same lot. One implicated platelet unit had been treated with pathogen-inactivation technology, and two had tested negative with a rapid bacterial detection device after negative primary culture. Because platelets are usually stored at room temperature, bacteria in contaminated platelet units can proliferate to clinically relevant levels by the time of transfusion. Clinicians should monitor for sepsis after platelet transfusions even after implementation of bacterial contamination mitigation strategies. Recognizing adverse transfusion reactions and reporting to the platelet supplier and hemovigilance systems is crucial for public health practitioners to detect and prevent sepsis associated with contaminated platelets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.