Evidence map›Paper›PMID 31194693›Full record

ReviewReviews in the neurosciences2019

Brain structure and cognitive ability in healthy aging: a review on longitudinal correlated change.

Jessica Oschwald, Sabrina Guye, Franziskus Liem, Philippe Rast, Sherry Willis, Christina Röcke, Lutz Jäncke, Mike Martin, Susan Mérillat

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Reviews in the neurosciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
137citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

137 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  13. Cardiovascular risk and hippocampal-cognitive coupling in Alzheimer's disease.medRxiv : the preprint server for health sciences · 2026
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77 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jessica OschwaldUniversity Research Priority Program 'Dynamics of Healthy Aging', University of Zurich, Andreasstrasse 15, CH-8050Zurich, Switzerland, Phone: +41 44 634 52 19.
Sabrina GuyeUniversity Research Priority Program 'Dynamics of Healthy Aging', University of Zurich, Andreasstrasse 15, CH-8050Zurich, Switzerland.
Franziskus LiemUniversity Research Priority Program 'Dynamics of Healthy Aging', University of Zurich, Andreasstrasse 15, CH-8050Zurich, Switzerland.
Philippe RastDepartment of Psychology, University of California, Davis, 1 Shields Avenue, Davis, CA 95616, USA.
Sherry WillisSeattle Longitudinal Study, Department of Psychiatry and Behavioral Sciences, University of Washington, 2500 Sixth Ave N., Apt. 1, Seattle, WA 98195, USA.
Christina RöckeUniversity Research Priority Program 'Dynamics of Healthy Aging', University of Zurich, Andreasstrasse 15, CH-8050Zurich, Switzerland.
Lutz JänckeUniversity Research Priority Program 'Dynamics of Healthy Aging', University of Zurich, Andreasstrasse 15, CH-8050Zurich, Switzerland.
Mike MartinUniversity Research Priority Program 'Dynamics of Healthy Aging', University of Zurich, Andreasstrasse 15, CH-8050Zurich, Switzerland.
Susan MérillatUniversity Research Priority Program 'Dynamics of Healthy Aging', University of Zurich, Andreasstrasse 15, CH-8050Zurich, Switzerland.

Funding

A Multi-Study Replication of the Predictive Value of Intra-Individual Variabilityon Long-Term Changes in Cognition, Health and AffectR01AG050720 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI RAST, PHILIPPE · 2016 to 2018
$741k
NIA NIH HHS R01 AG050720
6 · The paper itself

Abstract

Little is still known about the neuroanatomical substrates related to changes in specific cognitive abilities in the course of healthy aging, and the existing evidence is predominantly based on cross-sectional studies. However, to understand the intricate dynamics between developmental changes in brain structure and changes in cognitive ability, longitudinal studies are needed. In the present article, we review the current longitudinal evidence on correlated changes between magnetic resonance imaging-derived measures of brain structure (e.g. gray matter/white matter volume, cortical thickness), and laboratory-based measures of fluid cognitive ability (e.g. intelligence, memory, processing speed) in healthy older adults. To theoretically embed the discussion, we refer to the revised Scaffolding Theory of Aging and Cognition. We found 31 eligible articles, with sample sizes ranging from n = 25 to n = 731 (median n = 104), and participant age ranging from 19 to 103. Several of these studies report positive correlated changes for specific regions and specific cognitive abilities (e.g. between structures of the medial temporal lobe and episodic memory). However, the number of studies presenting converging evidence is small, and the large methodological variability between studies precludes general conclusions. Methodological and theoretical limitations are discussed. Clearly, more empirical evidence is needed to advance the field. Therefore, we provide guidance for future researchers by presenting ideas to stimulate theory and methods for development.

Indexed as

CognitionModels, NeurologicalAgingAnimalsBrainHumansbrain structurechangecognitive abilitycorrelated changehealthy aginglongitudinal

Identifiers

PMID31194693
PMCPMC8572130

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.