Evidence map›Paper›PMID 31194638›Full record

ArticleThyroid : official journal of the American Thyroid Association2019

Antigen-Specific Immunotherapy with Thyrotropin Receptor Peptides in Graves' Hyperthyroidism: A Phase I Study.

Simon H S Pearce, Colin Dayan, David C Wraith, Kevin Barrell, Natalie Olive, Lotta Jansson, Terrie Walker-Smith, Christina Carnegie, Keith F Martin, Kristien Boelaert and 9 more

Open access · hybridAbstract readClinical Trial, Phase I
In one paragraph

Article in Thyroid : official journal of the American Thyroid Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 12 institutions in 2 countries.

Simon H S Pearce1Institute for Genetic Medicine, Newcastle University, and Newcastle Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom.
Colin Dayan2Thyroid Research Group, School of Medicine, Cardiff University, Cardiff, United Kingdom.
David C Wraith3Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham United Kingdom.
Kevin Barrell4Apitope Technology (Bristol) Ltd., Chepstow, United Kingdom.
Natalie Olive4Apitope Technology (Bristol) Ltd., Chepstow, United Kingdom.
Lotta Jansson5Apitope International NV, Diepenbeek, Belgium.
Terrie Walker-Smith4Apitope Technology (Bristol) Ltd., Chepstow, United Kingdom.
Christina Carnegie4Apitope Technology (Bristol) Ltd., Chepstow, United Kingdom.
Keith F Martin4Apitope Technology (Bristol) Ltd., Chepstow, United Kingdom.
Kristien Boelaert6Institute of Metabolism and Systems Research, University of Birmingham, Birmingham United Kingdom.
Jackie Gilbert7Department of Endocrinology, King's College Hospital, London, United Kingdom.
Claire E Higham8Department of Endocrinology, Christie Hospital NHS Foundation Trust, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Ilaria Muller2Thyroid Research Group, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Robert D Murray9Department of Endocrinology, St. James's University Hospital, Leeds, United Kingdom.
Petros Perros10Endocrine Unit, Newcastle Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom.
Salman Razvi11Institute for Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
Bijay Vaidya12Macleod Diabetes & Endocrine Centre, Royal Devon and Exeter Hospital, Exeter, United Kingdom.
Florian Wernig13Department of Endocrinology, Imperial College, London, United Kingdom.
George J Kahaly14Department of Medicine I, Johannes Gutenberg University Medical Center, Mainz, Germany.
Cardiff University · GBJohannes Gutenberg University Mainz · DEKing's College Hospital · GBManchester Academic Health Science Centre · GBNewcastle University · GBNewcastle upon Tyne Hospital · GBNewcastle upon Tyne Hospitals NHS Foundation Trust · GBNIHR Birmingham Biomedical Research Centre · GBNIHR Imperial Biomedical Research Centre · GBRoyal Devon and Exeter Hospital · GBSt James's University Hospital · GBUniversity of Birmingham · GB

Funding

Department of HealthMedical Research Council G0500783
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultDesensitization, ImmunologicFemaleGraves DiseaseHumansImmunoglobulins, Thyroid-StimulatingInjections, IntradermalInjection Site ReactionMaleMiddle AgedPeptidesReceptors, ThyrotropinThyroxineTreatment OutcomeTriiodothyronineImmunoglobulins, Thyroid-StimulatingPeptidesReceptors, ThyrotropinThyroxineTriiodothyronineTSHR protein, humanautoimmune thyroid diseasedesensitizationGraves' diseaseimmunomodulationpeptide immunotherapythyroid stimulating hormone receptor

Identifiers

PMID31194638
PMCPMC6648194
OpenAlexW2950800950

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.